{"created":"2023-05-15T14:34:00.267429+00:00","id":44088,"links":{},"metadata":{"_buckets":{"deposit":"8cdf1305-3f69-42a9-825d-aeb7d5629007"},"_deposit":{"created_by":1,"id":"44088","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"44088"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00044088","sets":["1"]},"author_link":["438287","438286","438298","438293","438297","438289","438292","438285","438290","438295","438288","438294","438291","438296"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"1999-12","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"6","bibliographicPageEnd":"4000","bibliographicPageStart":"397","bibliographicVolumeNumber":"13","bibliographic_titles":[{"bibliographic_title":"Annals of Nuclear Medicine"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The kinetics of Yttrium-90 (Y-90) in bone of mice was investigated in combination with edetate calcium disodium (CaNa2EDTA). One goup of mice were intraperitoneally administered 37.5 mg/kg CaNa2EDTA or 0.9% NaCl as a control at 1,22,34,46,58,70,82,94,154 and 166 h after injection of Y-90 acetate (post-administration), and the biodistributuin was studied at 3,24,72,120 and 168 h postinjection of Y-90 acetate. No difference between the post-CaNa2EDTA-treated mice and the control was demonstrated in the radioactivity in the bone. A decrease in radioactivity in the liver and kidneys was accelerated, and the radioactivity was lower than the control at 120 h postinjection.  The other group of mice were also given the same dose of chelator at 12 h and 1 h preinjection of Y-90 acetate and at 1,22,34,46,58,70 82,94,154 and 166 h after injection of Y-90 acetate (pre- and post-administration), the radioactivity in bone at 3 h postinjection was signicicantly lower than in the control (24.4 3.92% ID/g vs. 31.7 2.26% ID/g, p<0.05), but the decrease was not sequential. A significant reduction in radioactivity in the blood, kidneys and liver was demonstrated at 3 h, 72 h and 72 h postinjection.  In conclusion, the CaNa2EDTA with the administration achedule employed here cannot chelate the Y-90 from bone but the free Y-90 before deposition into bone.","subitem_description_type":"Abstract"}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0914-7187","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Watanabe, Naoyuki"}],"nameIdentifiers":[{"nameIdentifier":"438285","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Oriuchi, Noboru"}],"nameIdentifiers":[{"nameIdentifier":"438286","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tanada, Shuji"}],"nameIdentifiers":[{"nameIdentifier":"438287","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Murata, Hajime"}],"nameIdentifiers":[{"nameIdentifier":"438288","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Inoue, Tomio"}],"nameIdentifiers":[{"nameIdentifier":"438289","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Sasaki, Yasuhito"}],"nameIdentifiers":[{"nameIdentifier":"438290","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Endou, Keigo"}],"nameIdentifiers":[{"nameIdentifier":"438291","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"et.al"}],"nameIdentifiers":[{"nameIdentifier":"438292","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"渡辺 直行","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"438293","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"棚田 修二","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"438294","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"村田 啓","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"438295","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"井上 登美夫","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"438296","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"佐々木 康人","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"438297","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"遠藤 啓吾","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"438298","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Effect of edetate calcium disodium on yttrium-90 activity in bone of mice","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Effect of edetate calcium disodium on yttrium-90 activity in bone of mice"}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2006-05-22"},"publish_date":"2006-05-22","publish_status":"0","recid":"44088","relation_version_is_last":true,"title":["Effect of edetate calcium disodium on yttrium-90 activity in bone of mice"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-16T00:19:34.589354+00:00"}