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Isolation and chromosomal assignment of a human gene encoding protein inhibitor of activated STAT3 (PIAS3).
https://repo.qst.go.jp/records/43904
https://repo.qst.go.jp/records/43904d7634610-0f13-438d-ae12-aa8532dadac7
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2005-12-16 | |||||
| タイトル | ||||||
| タイトル | Isolation and chromosomal assignment of a human gene encoding protein inhibitor of activated STAT3 (PIAS3). | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Ueki, Nobuhide
× Ueki, Nobuhide× Seki, Naohiko× Yano, Kazuhiro× Saito, Toshiyuki× Masuho, Yasuhiko× Muramatsu, Masa-aki× 関 直彦× 齋藤 俊行 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Mouse PIAS3 (protein inhibitor of activated STAT3) is a specific inhibitor of STAT3 that downregulates its signaling pathway. Here we report the isolation and chromosome mapping of the human PIAS3 gene. Human PIAS3 cDNA encoded a predicted protein of 619 aa which has 83% overall amino acid identity to the mouse counterpart. Based on polymerase chain reaction assisted analysis of a human/rodent mono-chromosomal hybrid cell panel and a radiation hybrid mapping panel, the human PIAS3 gene was mapped to the chromosome 1q21 region. Mapping of a crucial gene in modulating the STAT3 signaling pathway may provide new clues to the understanding of malignancies or genetic disorders caused by this chromosome region. | |||||
| 書誌情報 |
Journal of Human Genetics 巻 44, p. 193-196, 発行日 1999 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 1434-5161 | |||||
