@article{oai:repo.qst.go.jp:00043904, author = {Ueki, Nobuhide and Seki, Naohiko and Yano, Kazuhiro and Saito, Toshiyuki and Masuho, Yasuhiko and Muramatsu, Masa-aki and 関 直彦 and 齋藤 俊行}, journal = {Journal of Human Genetics}, month = {}, note = {Mouse PIAS3 (protein inhibitor of activated STAT3) is a specific inhibitor of STAT3 that downregulates its signaling pathway. Here we report the isolation and chromosome mapping of the human PIAS3 gene. Human PIAS3 cDNA encoded a predicted protein of 619 aa which has 83% overall amino acid identity to the mouse counterpart. Based on polymerase chain reaction assisted analysis of a human/rodent mono-chromosomal hybrid cell panel and a radiation hybrid mapping panel, the human PIAS3 gene was mapped to the chromosome 1q21 region. Mapping of a crucial gene in modulating the STAT3 signaling pathway may provide new clues to the understanding of malignancies or genetic disorders caused by this chromosome region.}, pages = {193--196}, title = {Isolation and chromosomal assignment of a human gene encoding protein inhibitor of activated STAT3 (PIAS3).}, volume = {44}, year = {1999} }