WEKO3
アイテム
4,5,9,10-Tetrahydro-1,4-ethanobenz[b]quinolizine as a Prodrug for Its Quinolizinium Cation as a Ligand to the Open State of the TCP-Binding Site of NMDA Receptors
https://repo.qst.go.jp/records/43644
https://repo.qst.go.jp/records/43644bbf16f70-098b-4def-bad4-022298503e1c
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2005-03-18 | |||||
| タイトル | ||||||
| タイトル | 4,5,9,10-Tetrahydro-1,4-ethanobenz[b]quinolizine as a Prodrug for Its Quinolizinium Cation as a Ligand to the Open State of the TCP-Binding Site of NMDA Receptors | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Sasaki, Shigeki
× Sasaki, Shigeki× Kanda, Takahiro× Ishibashi, Nobuyasu× Yamamoto, Fumihiko× Haradahira, Terushi× Okauchi, Takashi× Maeda, Jun× Suzuki, Kazutoshi× Maeda, Minoru× 佐々木 茂貴× 原田平 輝志× 岡内 隆× 前田 純× 鈴木 和年× 前田 稔 |
|||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | A new derivative of 4,5,9,10-tetrahydro-1,4-ethanobenz[b]quinolizine (2) has been designed as a prodrug for its quinolizinium cation (1) that is a potent antagonist of the TCP-binding site of NMDA receptors at the open state. The 11C-labeled 2 showed high accumulation of radioactivity in the brain in an in vivo biodistribution study. The speculation of 2 as a prodrug of 1 has been proven by the fact that 1 was observed in a high ratio to 2 in an analysis by RP-HPLC of the brain homogenates. 2001 Elsevier Science Ltd. All rights reserved. | |||||
| 書誌情報 |
Bioorganic & Medicinal Chemistry Letters 巻 11, p. 519-521, 発行日 2001 |
|||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0960-894X | |||||
