@article{oai:repo.qst.go.jp:00043644, author = {Sasaki, Shigeki and Kanda, Takahiro and Ishibashi, Nobuyasu and Yamamoto, Fumihiko and Haradahira, Terushi and Okauchi, Takashi and Maeda, Jun and Suzuki, Kazutoshi and Maeda, Minoru and 佐々木 茂貴 and 原田平 輝志 and 岡内 隆 and 前田 純 and 鈴木 和年 and 前田 稔}, journal = {Bioorganic & Medicinal Chemistry Letters}, month = {}, note = {A new derivative of 4,5,9,10-tetrahydro-1,4-ethanobenz[b]quinolizine (2) has been designed as a prodrug for its quinolizinium cation (1) that is a potent antagonist of the TCP-binding site of NMDA receptors at the open state. The 11C-labeled 2 showed high accumulation of radioactivity in the brain in an in vivo biodistribution study. The speculation of 2 as a prodrug of 1 has been proven by the fact that 1 was observed in a high ratio to 2 in an analysis by RP-HPLC of the brain homogenates. 2001 Elsevier Science Ltd. All rights reserved.}, pages = {519--521}, title = {4,5,9,10-Tetrahydro-1,4-ethanobenz[b]quinolizine as a Prodrug for Its Quinolizinium Cation as a Ligand to the Open State of the TCP-Binding Site of NMDA Receptors}, volume = {11}, year = {2001} }