{"created":"2023-05-15T14:33:38.743739+00:00","id":43644,"links":{},"metadata":{"_buckets":{"deposit":"dc6f45c1-4698-484c-9870-2f3f50e3c5b0"},"_deposit":{"created_by":1,"id":"43644","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"43644"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00043644","sets":["1"]},"author_link":["433934","433936","433941","433939","433933","433943","433937","433942","433932","433931","433930","433935","433938","433929","433940"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2001","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"521","bibliographicPageStart":"519","bibliographicVolumeNumber":"11","bibliographic_titles":[{"bibliographic_title":"Bioorganic & Medicinal Chemistry Letters"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"A new derivative of 4,5,9,10-tetrahydro-1,4-ethanobenz[b]quinolizine (2) has been designed as a prodrug for its quinolizinium cation (1) that is a potent antagonist of the TCP-binding site of NMDA receptors at the open state. The 11C-labeled 2 showed high accumulation of radioactivity in the brain in an in vivo biodistribution study. The speculation of 2 as a prodrug of 1 has been proven by the fact that 1 was observed in a high ratio to 2 in an analysis by RP-HPLC of the brain homogenates.  2001 Elsevier Science Ltd. All rights reserved.","subitem_description_type":"Abstract"}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0960-894X","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Sasaki, Shigeki"}],"nameIdentifiers":[{"nameIdentifier":"433929","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kanda, Takahiro"}],"nameIdentifiers":[{"nameIdentifier":"433930","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ishibashi, Nobuyasu"}],"nameIdentifiers":[{"nameIdentifier":"433931","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yamamoto, Fumihiko"}],"nameIdentifiers":[{"nameIdentifier":"433932","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Haradahira, Terushi"}],"nameIdentifiers":[{"nameIdentifier":"433933","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Okauchi, Takashi"}],"nameIdentifiers":[{"nameIdentifier":"433934","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Maeda, Jun"}],"nameIdentifiers":[{"nameIdentifier":"433935","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Suzuki, Kazutoshi"}],"nameIdentifiers":[{"nameIdentifier":"433936","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Maeda, Minoru"}],"nameIdentifiers":[{"nameIdentifier":"433937","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"佐々木 茂貴","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"433938","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"原田平 輝志","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"433939","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"岡内 隆","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"433940","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"前田 純","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"433941","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"鈴木 和年","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"433942","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"前田 稔","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"433943","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"4,5,9,10-Tetrahydro-1,4-ethanobenz[b]quinolizine as a Prodrug for Its Quinolizinium Cation as a Ligand to the Open State of the TCP-Binding Site of NMDA Receptors","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"4,5,9,10-Tetrahydro-1,4-ethanobenz[b]quinolizine as a Prodrug for Its Quinolizinium Cation as a Ligand to the Open State of the TCP-Binding Site of NMDA Receptors"}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2005-03-18"},"publish_date":"2005-03-18","publish_status":"0","recid":"43644","relation_version_is_last":true,"title":["4,5,9,10-Tetrahydro-1,4-ethanobenz[b]quinolizine as a Prodrug for Its Quinolizinium Cation as a Ligand to the Open State of the TCP-Binding Site of NMDA Receptors"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-16T00:24:46.515931+00:00"}