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Synthesis and Evaluation of 18F-and 11C-Labelled 9,10-Ethanobenzo[b]quinolizinium Derivatives for Imaging of the NMDA Receptor at the TCP-Binding Site
https://repo.qst.go.jp/records/43641
https://repo.qst.go.jp/records/4364121b83c2a-b82d-45bb-b3ac-b152cd866887
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2005-03-02 | |||||
| タイトル | ||||||
| タイトル | Synthesis and Evaluation of 18F-and 11C-Labelled 9,10-Ethanobenzo[b]quinolizinium Derivatives for Imaging of the NMDA Receptor at the TCP-Binding Site | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Ishibashi, Nobuyasu
× Ishibashi, Nobuyasu× Kuwamura, T× Sano, H× Yamamoto, Fumihiko× Haradahira, Terushi× Suzuki, Kazutoshi× Suhara, Tetsuya× Sasaki, Shigeki× Maeda, Minoru× 原田平 輝志× 鈴木 和年× 須原 哲也× 佐々木 茂貴× 前田 稔 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Derivatives of 9,10-ethanobenzo[b]quinolizinium are potent antagonists of the TCP-site of the NMDA receptor. Two fluoroethyl-substituted analogues were labelled with fluorine-18 by displacement of the tosylate with [18F]fluoride, followed by a Diels-Alder reaction. A methoxy-substituted analogue labelled with carbon-11 was obtained by O-methylation of the corresponding hydroxy precursor with [11C]iodomethane. In biodistribution studies in mice with these three radioligands, it was found that they have little ability to penetrate the blood-brain barrier. | |||||
| 書誌情報 |
Journal of Labelled Compounds & Radiopharmaceuticals 巻 43, p. 375-383, 発行日 2000 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0362-4803 | |||||
