@article{oai:repo.qst.go.jp:00043641, author = {Ishibashi, Nobuyasu and Kuwamura, T and Sano, H and Yamamoto, Fumihiko and Haradahira, Terushi and Suzuki, Kazutoshi and Suhara, Tetsuya and Sasaki, Shigeki and Maeda, Minoru and 原田平 輝志 and 鈴木 和年 and 須原 哲也 and 佐々木 茂貴 and 前田 稔}, journal = {Journal of Labelled Compounds & Radiopharmaceuticals}, month = {}, note = {Derivatives of 9,10-ethanobenzo[b]quinolizinium are potent antagonists of the TCP-site of the NMDA receptor. Two fluoroethyl-substituted analogues were labelled with fluorine-18 by displacement of the tosylate with [18F]fluoride, followed by a Diels-Alder reaction. A methoxy-substituted analogue labelled with carbon-11 was obtained by O-methylation of the corresponding hydroxy precursor with [11C]iodomethane. In biodistribution studies in mice with these three radioligands, it was found that they have little ability to penetrate the blood-brain barrier.}, pages = {375--383}, title = {Synthesis and Evaluation of 18F-and 11C-Labelled 9,10-Ethanobenzo[b]quinolizinium Derivatives for Imaging of the NMDA Receptor at the TCP-Binding Site}, volume = {43}, year = {2000} }