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DNA-dependent protein kinase enhances DNA damage-induced apoptosis in association with Friend gp70
https://repo.qst.go.jp/records/43637
https://repo.qst.go.jp/records/43637955e6daa-dc4c-4714-ba1f-6f1b09ffcedd
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2005-02-15 | |||||
| タイトル | ||||||
| タイトル | DNA-dependent protein kinase enhances DNA damage-induced apoptosis in association with Friend gp70 | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Yamaguchi, Shuichi
× Yamaguchi, Shuichi× Hasegawa, Maki× Aizawa, Shirou× Tanaka, Kaoru× Yoshida, Kazuko× Noda, Yuko× Tatsumi, Kouichi× Hirokawa, Katsuiku× Kitagawa, Masanobu× 山口 修一× 長谷川 真紀× 相澤 志郎× 田中 薫× 吉田 和子× 野田 攸子× 巽 紘一× 北川 昌伸 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Friend leukemia virus (FLV) infection strongly enhances gamma-irradiation-induced apoptosis of hematopoietic cells of C3H hosts leading to a lethal anemia. Experiments using p53 knockout mice with the C3H background have clarified that the apoptosis is p53-dependent and would not be associated with changes of cell populations caused by the infection with FLV. In bone marrow cells of FLV + total body irradiation (TBI)-treated C3H mice, the p53 protein was prominently activated to overexpress p21 and bax suggesting that apoptosis-enhancing mechanisms lay upstream of p53 protein in the signaling pathway. Neither of DNA-dependent protein kinase (DNA-PK)-deficient SCID mice nor ataxia telangiectasia mutated (ATM) gene knockout mice with the C3H background exhibited a remarkable enhancement of apoptosis or p53 activation on FLV + TBI-treatment indicating that DNA-PK and ATM were both essential. ATM appeared necessary for introducing DNA damage-induced apoptosis, while DNA-PK enhanced p53-dependent apoptosis under FLV-infection. Surprisingly, viral envelope protein, gp70, was co-precipitated with DNA-PK but not with ATM in FLV + TBI-treated C3H mice. These results indicated that FLV-infection enhances DNA damage-induced apoptosis via p53 activation and that DNA-PK, in association with gp70, might play critical roles in modulating the signaling pathway. | |||||
| 書誌情報 |
Leukemia Research 巻 29, 号 3, p. 307-316, 発行日 2005-03 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0145-2126 | |||||
