@article{oai:repo.qst.go.jp:00043637,
 author = {Yamaguchi, Shuichi and Hasegawa, Maki and Aizawa, Shirou and Tanaka, Kaoru and Yoshida, Kazuko and Noda, Yuko and Tatsumi, Kouichi and Hirokawa, Katsuiku and Kitagawa, Masanobu and 山口 修一 and 長谷川 真紀 and 相澤 志郎 and 田中 薫 and 吉田 和子 and 野田 攸子 and 巽 紘一 and 北川 昌伸},
 issue = {3},
 journal = {Leukemia Research},
 month = {Mar},
 note = {Friend leukemia virus (FLV) infection strongly enhances gamma-irradiation-induced apoptosis of hematopoietic cells of C3H hosts leading to a lethal anemia. Experiments using p53 knockout mice with the C3H background have clarified that the apoptosis is p53-dependent and would not be associated with changes of cell populations caused by the infection with FLV. In bone marrow cells of FLV + total body irradiation (TBI)-treated C3H mice, the p53 protein was prominently activated to overexpress p21 and bax suggesting that apoptosis-enhancing mechanisms lay upstream of p53 protein in the signaling pathway. Neither of DNA-dependent protein kinase (DNA-PK)-deficient SCID mice nor ataxia telangiectasia mutated (ATM) gene knockout mice with the C3H background exhibited a remarkable enhancement of apoptosis or p53 activation on FLV + TBI-treatment indicating that DNA-PK and ATM were both essential. ATM appeared necessary for introducing DNA damage-induced apoptosis, while DNA-PK enhanced p53-dependent apoptosis under FLV-infection. Surprisingly, viral envelope protein, gp70, was co-precipitated with DNA-PK but not with ATM in FLV + TBI-treated C3H mice. These results indicated that FLV-infection enhances DNA damage-induced apoptosis via p53 activation and that DNA-PK, in association with gp70, might play critical roles in modulating the signaling pathway.},
 pages = {307--316},
 title = {DNA-dependent protein kinase enhances DNA damage-induced apoptosis in association with Friend gp70},
 volume = {29},
 year = {2005}
}