{"created":"2023-05-15T14:33:38.426742+00:00","id":43637,"links":{},"metadata":{"_buckets":{"deposit":"27b13b15-7a4b-4e2f-a0c4-858d90975cc0"},"_deposit":{"created_by":1,"id":"43637","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"43637"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00043637","sets":["1"]},"author_link":["433863","433868","433859","433858","433866","433864","433869","433861","433856","433867","433860","433865","433857","433870","433862","433855","433854"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2005-03","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"3","bibliographicPageEnd":"316","bibliographicPageStart":"307","bibliographicVolumeNumber":"29","bibliographic_titles":[{"bibliographic_title":"Leukemia Research"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Friend leukemia virus (FLV) infection strongly enhances gamma-irradiation-induced apoptosis of hematopoietic cells of C3H hosts leading to a lethal anemia. Experiments using p53 knockout mice with the C3H background have clarified that the apoptosis is p53-dependent and would not be associated with changes of cell populations caused by the infection with FLV. In bone marrow cells of FLV + total body irradiation (TBI)-treated C3H mice, the p53 protein was prominently activated to overexpress p21 and bax suggesting that apoptosis-enhancing mechanisms lay upstream of p53 protein in the signaling pathway. Neither of DNA-dependent protein kinase (DNA-PK)-deficient SCID mice nor ataxia telangiectasia mutated (ATM) gene knockout mice with the C3H background exhibited a remarkable enhancement of apoptosis or p53 activation on FLV + TBI-treatment indicating that DNA-PK and ATM were both essential. ATM appeared necessary for introducing DNA damage-induced apoptosis, while DNA-PK enhanced p53-dependent apoptosis under FLV-infection. Surprisingly, viral envelope protein, gp70, was co-precipitated with DNA-PK but not with ATM in FLV + TBI-treated C3H mice. These results indicated that FLV-infection enhances DNA damage-induced apoptosis via p53 activation and that DNA-PK, in association with gp70, might play critical roles in modulating the signaling pathway.","subitem_description_type":"Abstract"}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0145-2126","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Yamaguchi, Shuichi"}],"nameIdentifiers":[{"nameIdentifier":"433854","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hasegawa, Maki"}],"nameIdentifiers":[{"nameIdentifier":"433855","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Aizawa, Shirou"}],"nameIdentifiers":[{"nameIdentifier":"433856","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tanaka, Kaoru"}],"nameIdentifiers":[{"nameIdentifier":"433857","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yoshida, Kazuko"}],"nameIdentifiers":[{"nameIdentifier":"433858","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Noda, Yuko"}],"nameIdentifiers":[{"nameIdentifier":"433859","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tatsumi, Kouichi"}],"nameIdentifiers":[{"nameIdentifier":"433860","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hirokawa, Katsuiku"}],"nameIdentifiers":[{"nameIdentifier":"433861","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kitagawa, Masanobu"}],"nameIdentifiers":[{"nameIdentifier":"433862","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"山口 修一","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"433863","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"長谷川 真紀","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"433864","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"相澤 志郎","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"433865","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"田中 薫","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"433866","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"吉田 和子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"433867","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"野田 攸子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"433868","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"巽 紘一","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"433869","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"北川 昌伸","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"433870","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"DNA-dependent protein kinase enhances DNA damage-induced apoptosis in association with Friend gp70","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"DNA-dependent protein kinase enhances DNA damage-induced apoptosis in association with Friend gp70"}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2005-02-15"},"publish_date":"2005-02-15","publish_status":"0","recid":"43637","relation_version_is_last":true,"title":["DNA-dependent protein kinase enhances DNA damage-induced apoptosis in association with Friend gp70"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-16T00:24:51.480109+00:00"}