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Pre-B-Cell Lymphomas in Mice Following Injection of 239Pu Citrate: Comparison with MNU-Induced T-Lymphoblastic Lymphomas
https://repo.qst.go.jp/records/43567
https://repo.qst.go.jp/records/435672281cb32-23f3-477a-b459-c291283c5301
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2004-12-15 | |||||
| タイトル | ||||||
| タイトル | Pre-B-Cell Lymphomas in Mice Following Injection of 239Pu Citrate: Comparison with MNU-Induced T-Lymphoblastic Lymphomas | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Oghiso, Yoichi
× Oghiso, Yoichi× Yamada, Yutaka× 小木曽 洋一× 山田 裕 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Lymphoid neoplasms occurring in three different (C3H/He, C57BL/6, and B6C3F1) strains of female mice after injection of the bone-seeking and alpha-emitting radionuclide, 239Pu citrate were compared by immunohistochemistry with those from the alkylating agent, N-methyl-N-nitrosourea (MNU)-injected mice. There was a variety of phenotypes from either T-cell to B-cell or histiocytic lineages in lymphoid neoplasms of the control, saline-injected mice. While strain differences were noted in the incidence and proportion, lymphoid neoplasms occurring early after 239Pu-injection were, however, characterized by B220+ phenotypes but negative for both T-cell-specific markers (Thy1, CD3) and B-cell markers (CD5, CD19, CD79b) to be classified into pre-B-cell lymphomas derived from progenitor B-cells. In contrast, almost all the MNU-induced lymphomas were shown to be CD3+ or rarely Thy1+ but B220- T-lymphoblastic lymphomas. These results indicate differences in immunophenotypic expression but also might reflect different carcinogenic processes between chemical- and radiation-induced murine lymphomas. | |||||
| 書誌情報 |
Journal of Toxicologic Pathology 巻 16, p. 93-102, 発行日 2003 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0914-9198 | |||||
