@article{oai:repo.qst.go.jp:00043567,
 author = {Oghiso, Yoichi and Yamada, Yutaka and 小木曽 洋一 and 山田 裕},
 journal = {Journal of Toxicologic Pathology},
 month = {},
 note = {Lymphoid neoplasms occurring in three different (C3H/He, C57BL/6, and B6C3F1) strains of female mice after injection of the bone-seeking and alpha-emitting radionuclide, 239Pu citrate were compared by immunohistochemistry with those from the alkylating agent, N-methyl-N-nitrosourea (MNU)-injected mice.  There was a variety of phenotypes from either T-cell to B-cell or histiocytic lineages in lymphoid neoplasms of the control, saline-injected mice.  While strain differences were noted in the incidence and proportion, lymphoid neoplasms occurring early after 239Pu-injection were, however, characterized by B220+ phenotypes but negative for both T-cell-specific markers (Thy1, CD3) and B-cell markers (CD5, CD19, CD79b) to be classified into pre-B-cell lymphomas derived from progenitor B-cells.  In contrast, almost all the MNU-induced lymphomas were shown to be CD3+ or rarely Thy1+ but B220- T-lymphoblastic lymphomas.  These results indicate differences in immunophenotypic expression but also might reflect different carcinogenic processes between chemical- and radiation-induced murine lymphomas.},
 pages = {93--102},
 title = {Pre-B-Cell Lymphomas in Mice Following Injection of 239Pu Citrate: Comparison with MNU-Induced T-Lymphoblastic Lymphomas},
 volume = {16},
 year = {2003}
}