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Effects of Carbon-Ion Radiation on the Postnatal Development of Mice and on the Yield of White Spots in the Mid-Ventrum and Tail Tips
https://repo.qst.go.jp/records/43532
https://repo.qst.go.jp/records/43532502c7aa7-d328-488e-b267-8484888edde8
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2004-11-05 | |||||
| タイトル | ||||||
| タイトル | Effects of Carbon-Ion Radiation on the Postnatal Development of Mice and on the Yield of White Spots in the Mid-Ventrum and Tail Tips | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Hirobe, Tomohisa
× Hirobe, Tomohisa× Eguchi-Kasai, Kiyomi× Murakami, Masahiro× 廣部 知久× 笠井 清美× 村上 正弘 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Pregnant females of C57BL/10JHir mice at 9 days of gestation were whole-body irradiated with a single acute dose of carbon ion-radiations. Average linear energy transfer (LET) of carbon ion-radiations was 50 keV/um within a spread-out-Bragg-peak (SOBP). The effect was studied by scoring changes in the postnatal development of mice as well as in the pigmentation of cutaneous coats and tail-tips of offspring 22 days after birth. The percentage of birth was reduced in mice exposed to carbon ion-radiations at doses greater than 0.5 Gy. The survival to day 22 was also reduced in mice exposed to carbon ion-radiations at doses greater than 0.75 Gy. Moreover, the body weight at day 22 was reduced in mice exposed to carbon ion-radiations at doses greater than 0.1 Gy. By comparing the survival to day 22 for carbon ion-radiations with that of our previous data of 60Co-g-rays, carbon ion-radiations were twice as effective as g-rays. White spots were found in the mid-ventrum as well as in the tail-tips of offspring exposed to carbon ion-radiations. The frequency and the size of the white spots in the mid-ventrum as well as in the tail-tips increased as the dose increased. Carbon ion-radiations seem to be slightly more effective than g-rays reported in our previous paper. In the ventral white spots, no melanocytes were observed in the epidermis, dermis and hair follicles. These results indicate that prenatal carbon-ion radiations have a greater effect on postnatal development and survival of mice than do g-rays; and that the relative biological effectiveness is greater than that for effects on melanocyte development. | |||||
| 書誌情報 |
Radiation Research 巻 162, 号 5, p. 580-584, 発行日 2004-11 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0033-7587 | |||||
