@article{oai:repo.qst.go.jp:00043532,
 author = {Hirobe, Tomohisa and Eguchi-Kasai, Kiyomi and Murakami, Masahiro and 廣部 知久 and 笠井 清美 and 村上 正弘},
 issue = {5},
 journal = {Radiation Research},
 month = {Nov},
 note = {Pregnant females of C57BL/10JHir mice at 9 days of gestation were whole-body irradiated with a single acute dose of carbon ion-radiations. Average linear energy transfer (LET) of carbon ion-radiations was 50 keV/um within a spread-out-Bragg-peak (SOBP). The effect was studied by scoring changes in the postnatal development of mice as well as in the pigmentation of cutaneous coats and tail-tips of offspring 22 days after birth. The percentage of birth was reduced in mice exposed to carbon ion-radiations at doses greater than 0.5 Gy. The survival to day 22 was also reduced in mice exposed to carbon ion-radiations at doses greater than 0.75 Gy. Moreover, the body weight at day 22 was reduced in mice exposed to carbon ion-radiations at doses greater than 0.1 Gy. By comparing the survival to day 22 for carbon ion-radiations with that of our previous data of 60Co-g-rays, carbon ion-radiations were twice as effective as g-rays. White spots were found in the mid-ventrum as well as in the tail-tips of offspring exposed to carbon ion-radiations. The frequency and the size of the white spots in the mid-ventrum as well as in the tail-tips increased as the dose increased. Carbon ion-radiations seem to be slightly more effective than g-rays reported in our previous paper. In the ventral white spots, no melanocytes were observed in the epidermis, dermis and hair follicles. These results indicate that prenatal carbon-ion radiations have a greater effect on postnatal development and survival of mice than do g-rays; and that the relative biological effectiveness is greater than that for effects on melanocyte development.},
 pages = {580--584},
 title = {Effects of Carbon-Ion Radiation on the Postnatal Development of Mice and on the Yield of White Spots in the Mid-Ventrum and Tail Tips},
 volume = {162},
 year = {2004}
}