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Elevated Interleukin-9 Receptor Expression and Response to Interleukins-9 and -7 in Thymocytes during Radiation-Induced T-Cell Lymphomagenesis in B6C3F1 Mice
https://repo.qst.go.jp/records/43312
https://repo.qst.go.jp/records/433122090fc6e-c4d6-4137-a5be-24a8c29cbd21
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2003-12-25 | |||||
| タイトル | ||||||
| タイトル | Elevated Interleukin-9 Receptor Expression and Response to Interleukins-9 and -7 in Thymocytes during Radiation-Induced T-Cell Lymphomagenesis in B6C3F1 Mice | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Nishimura, Mayumi
× Nishimura, Mayumi× Kakinuma, Shizuko× Yamamoto, Daisuke× Kobayashi, Yoshiro× Suzuki, Gen× Sado, Toshihiko× Shimada, Yoshiya× 西村 まゆみ× 柿沼 志津子× 鈴木 元× 佐渡 敏彦× 島田 義也 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Dysregulation of cytokine receptor expression and responsiveness to cytokines is hypothesized to play an important role in the development and expansion of preneoplastic cells or progression of neoplastic cells during the early and late stages of leukemogenesis. To determine the crucial changes in initiated cells that confer significant growth during the early stage of radiation-induced lymphomagenesis, we examined both the expression of receptors for thymus-derived cytokines and thymocyte response to cytokines before the onset of T cell lymphomas in B6C3F1 mice after split-dose irradiation. After irradiation, thymic T cell subsets underwent delayed regeneration consisting of two phases as determined by receptor expression. The first phase occurred within one week post-irradiation and was accompanied by transient expansion of T cell subsets strongly expressing receptor genes for IL-1, IL-2, IL-6, IL-7, IL-15 and TNFa. The second phase occurred 12 weeks after irradiation and was characterized by increased expression of IL-9Ra. Thymocytes from non-irradiated control mice were unresponsive to IL-9. However, IL-9 acted synergistically with IL-7 and PHA to stimulate the proliferation of irradiated cells during the second post-irradiation phase. Moreover, these cells showed hyper-responsiveness to IL-7 or PHA alone compared to age-matched non-irradiated control thymocytes. These results suggest that the unusual expression of IL-9 receptors and/or increased responsiveness of thymocytes to cytokines are key processes in the development of radiation-induced T cell lymphomas. |
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| 書誌情報 |
Journal of Cellular Physiology 巻 198, 号 1, p. 82-90, 発行日 2004-01 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0021-9541 | |||||
