{"created":"2023-05-15T14:33:23.873927+00:00","id":43312,"links":{},"metadata":{"_buckets":{"deposit":"43c18bf2-42a7-449f-a0c3-f6f36c6f5121"},"_deposit":{"created_by":1,"id":"43312","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"43312"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00043312","sets":["1"]},"author_link":["430841","430849","430848","430838","430845","430840","430844","430839","430847","430846","430843","430842"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2004-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"90","bibliographicPageStart":"82","bibliographicVolumeNumber":"198","bibliographic_titles":[{"bibliographic_title":"Journal of Cellular Physiology"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Dysregulation of cytokine receptor expression and responsiveness to\ncytokines is hypothesized to play an important role in the development and\nexpansion of preneoplastic cells or progression of neoplastic cells during\nthe early and late stages of leukemogenesis. To determine the crucial\nchanges in initiated cells that confer significant growth during the early\nstage of radiation-induced lymphomagenesis, we examined both the expression\nof receptors for thymus-derived cytokines and thymocyte response to\ncytokines before the onset of T cell lymphomas in B6C3F1 mice after\nsplit-dose irradiation. After irradiation, thymic T cell subsets underwent\ndelayed regeneration consisting of two phases as determined by receptor\nexpression. The first phase occurred within one week post-irradiation and\nwas accompanied by transient expansion of T cell subsets strongly expressing\nreceptor genes for IL-1, IL-2, IL-6, IL-7, IL-15 and TNFa. The second phase\noccurred 12 weeks after irradiation and was characterized by increased\nexpression of IL-9Ra. Thymocytes from non-irradiated control mice were\nunresponsive to IL-9. However, IL-9 acted synergistically with IL-7 and PHA\nto stimulate the proliferation of irradiated cells during the second\npost-irradiation phase. Moreover, these cells showed hyper-responsiveness to\nIL-7 or PHA alone compared to age-matched non-irradiated control thymocytes.\nThese results suggest that the unusual expression of IL-9 receptors and/or\nincreased responsiveness of thymocytes to cytokines are key processes in the\ndevelopment of radiation-induced T cell lymphomas.","subitem_description_type":"Abstract"}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0021-9541","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Nishimura, Mayumi"}],"nameIdentifiers":[{"nameIdentifier":"430838","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kakinuma, Shizuko"}],"nameIdentifiers":[{"nameIdentifier":"430839","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yamamoto, Daisuke"}],"nameIdentifiers":[{"nameIdentifier":"430840","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kobayashi, Yoshiro"}],"nameIdentifiers":[{"nameIdentifier":"430841","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Suzuki, Gen"}],"nameIdentifiers":[{"nameIdentifier":"430842","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Sado, Toshihiko"}],"nameIdentifiers":[{"nameIdentifier":"430843","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Shimada, Yoshiya"}],"nameIdentifiers":[{"nameIdentifier":"430844","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"西村 まゆみ","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"430845","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"柿沼 志津子","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"430846","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"鈴木 元","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"430847","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"佐渡 敏彦","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"430848","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"島田 義也","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"430849","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Elevated Interleukin-9 Receptor Expression and Response to Interleukins-9 and -7 in Thymocytes during Radiation-Induced T-Cell Lymphomagenesis in B6C3F1 Mice","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Elevated Interleukin-9 Receptor Expression and Response to Interleukins-9 and -7 in Thymocytes during Radiation-Induced T-Cell Lymphomagenesis in B6C3F1 Mice"}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2003-12-25"},"publish_date":"2003-12-25","publish_status":"0","recid":"43312","relation_version_is_last":true,"title":["Elevated Interleukin-9 Receptor Expression and Response to Interleukins-9 and -7 in Thymocytes during Radiation-Induced T-Cell Lymphomagenesis in B6C3F1 Mice"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-16T00:28:48.776374+00:00"}