@article{oai:repo.qst.go.jp:00043312,
 author = {Nishimura, Mayumi and Kakinuma, Shizuko and Yamamoto, Daisuke and Kobayashi, Yoshiro and Suzuki, Gen and Sado, Toshihiko and Shimada, Yoshiya and 西村 まゆみ and 柿沼 志津子 and 鈴木 元 and 佐渡 敏彦 and 島田 義也},
 issue = {1},
 journal = {Journal of Cellular Physiology},
 month = {Jan},
 note = {Dysregulation of cytokine receptor expression and responsiveness to
cytokines is hypothesized to play an important role in the development and
expansion of preneoplastic cells or progression of neoplastic cells during
the early and late stages of leukemogenesis. To determine the crucial
changes in initiated cells that confer significant growth during the early
stage of radiation-induced lymphomagenesis, we examined both the expression
of receptors for thymus-derived cytokines and thymocyte response to
cytokines before the onset of T cell lymphomas in B6C3F1 mice after
split-dose irradiation. After irradiation, thymic T cell subsets underwent
delayed regeneration consisting of two phases as determined by receptor
expression. The first phase occurred within one week post-irradiation and
was accompanied by transient expansion of T cell subsets strongly expressing
receptor genes for IL-1, IL-2, IL-6, IL-7, IL-15 and TNFa. The second phase
occurred 12 weeks after irradiation and was characterized by increased
expression of IL-9Ra. Thymocytes from non-irradiated control mice were
unresponsive to IL-9. However, IL-9 acted synergistically with IL-7 and PHA
to stimulate the proliferation of irradiated cells during the second
post-irradiation phase. Moreover, these cells showed hyper-responsiveness to
IL-7 or PHA alone compared to age-matched non-irradiated control thymocytes.
These results suggest that the unusual expression of IL-9 receptors and/or
increased responsiveness of thymocytes to cytokines are key processes in the
development of radiation-induced T cell lymphomas.},
 pages = {82--90},
 title = {Elevated Interleukin-9 Receptor Expression and Response to Interleukins-9 and -7 in Thymocytes during Radiation-Induced T-Cell Lymphomagenesis in B6C3F1 Mice},
 volume = {198},
 year = {2004}
}