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Comparisons of Pulmonary Carcinogenesis in Rats Following Inhalation Exposure to Pultonium Dioxide or X-ray Irradiation
https://repo.qst.go.jp/records/43261
https://repo.qst.go.jp/records/4326180e8e404-1014-43e9-a457-288568356009
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2003-11-12 | |||||
| タイトル | ||||||
| タイトル | Comparisons of Pulmonary Carcinogenesis in Rats Following Inhalation Exposure to Pultonium Dioxide or X-ray Irradiation | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Oghiso, Yoichi
× Oghiso, Yoichi× Yamada, Yutaka× 小木曽 洋一× 山田 裕 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Radiation-induced pulmonary carcinogenesis was compared in female Wistar rats following either inhalation exposure to alpha-emitting 239PuO2 aerosols, whole-body or thoracic X-ray irradiation. Dose-dependent survival reduction was correlated with increased malignant lung tumors at doses over 0.45 Gy, reaching the maximum incidence of 90% at 6.6-8.5 Gy in 239Pu-exposed rats. While the deffrential dose responses for each histopathological type of tumors were noted, almost 70-80% were carcinomas among all of the primary tumors from 239Pu-exposed rats. As the dose response curves for lung carcinomas were compared, the slope of the fit linear equation and the calculated relative effectiveness for 50% incidence of lung carcinomas of tumor lesions distributed in the lung per tumor-bearing animal were about 2-fold more in 239Pu-exposed rats, while the proportions of their histopathological types were similar between 239Pu-exposure and X-irradiation. These results indicate that the magnitudes of the relative effectiveness or risk for pulmonary carcinogenesis are greater in 239Pu-exposure than X-irradiation, and that radiation-induced lung tumors appear to originate mostly from the same target epithelial cells. | |||||
| 書誌情報 |
Journal of Radiation Research 巻 44, p. 261-270, 発行日 2003-09 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0449-3060 | |||||
