{"created":"2023-05-15T14:33:21.610599+00:00","id":43261,"links":{},"metadata":{"_buckets":{"deposit":"e1222408-d097-491b-bb6b-8b2fc60d32f6"},"_deposit":{"created_by":1,"id":"43261","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"43261"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00043261","sets":["1"]},"author_link":["430345","430343","430344","430346"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2003-09","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"270","bibliographicPageStart":"261","bibliographicVolumeNumber":"44","bibliographic_titles":[{"bibliographic_title":"Journal of Radiation Research"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Radiation-induced pulmonary carcinogenesis was compared in female Wistar rats following either inhalation exposure to alpha-emitting 239PuO2 aerosols, whole-body or thoracic X-ray irradiation.  Dose-dependent survival reduction was correlated with increased malignant lung tumors at doses over 0.45 Gy, reaching the maximum incidence of 90% at 6.6-8.5 Gy in 239Pu-exposed rats.  While the deffrential dose responses for each histopathological type of tumors were noted, almost 70-80% were carcinomas among all of the primary tumors from 239Pu-exposed rats.  As the dose response curves for lung carcinomas were compared, the slope of the fit linear equation and the calculated relative effectiveness for 50% incidence of lung carcinomas of tumor lesions distributed in the lung per tumor-bearing animal were about 2-fold more in 239Pu-exposed rats, while the proportions of their histopathological types were similar between 239Pu-exposure and X-irradiation.  These results indicate that the magnitudes of the relative effectiveness or risk for pulmonary carcinogenesis are greater in 239Pu-exposure than X-irradiation, and that radiation-induced lung tumors appear to originate mostly from the same target epithelial cells.","subitem_description_type":"Abstract"}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0449-3060","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Oghiso, Yoichi"}],"nameIdentifiers":[{"nameIdentifier":"430343","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yamada, Yutaka"}],"nameIdentifiers":[{"nameIdentifier":"430344","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"小木曽 洋一","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"430345","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"山田 裕","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"430346","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Comparisons of Pulmonary Carcinogenesis in Rats Following Inhalation Exposure to Pultonium Dioxide or X-ray Irradiation","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Comparisons of Pulmonary Carcinogenesis in Rats Following Inhalation Exposure to Pultonium Dioxide or X-ray Irradiation"}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2003-11-12"},"publish_date":"2003-11-12","publish_status":"0","recid":"43261","relation_version_is_last":true,"title":["Comparisons of Pulmonary Carcinogenesis in Rats Following Inhalation Exposure to Pultonium Dioxide or X-ray Irradiation"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-16T00:29:24.243482+00:00"}