@article{oai:repo.qst.go.jp:00043261,
 author = {Oghiso, Yoichi and Yamada, Yutaka and 小木曽 洋一 and 山田 裕},
 journal = {Journal of Radiation Research},
 month = {Sep},
 note = {Radiation-induced pulmonary carcinogenesis was compared in female Wistar rats following either inhalation exposure to alpha-emitting 239PuO2 aerosols, whole-body or thoracic X-ray irradiation.  Dose-dependent survival reduction was correlated with increased malignant lung tumors at doses over 0.45 Gy, reaching the maximum incidence of 90% at 6.6-8.5 Gy in 239Pu-exposed rats.  While the deffrential dose responses for each histopathological type of tumors were noted, almost 70-80% were carcinomas among all of the primary tumors from 239Pu-exposed rats.  As the dose response curves for lung carcinomas were compared, the slope of the fit linear equation and the calculated relative effectiveness for 50% incidence of lung carcinomas of tumor lesions distributed in the lung per tumor-bearing animal were about 2-fold more in 239Pu-exposed rats, while the proportions of their histopathological types were similar between 239Pu-exposure and X-irradiation.  These results indicate that the magnitudes of the relative effectiveness or risk for pulmonary carcinogenesis are greater in 239Pu-exposure than X-irradiation, and that radiation-induced lung tumors appear to originate mostly from the same target epithelial cells.},
 pages = {261--270},
 title = {Comparisons of Pulmonary Carcinogenesis in Rats Following Inhalation Exposure to Pultonium Dioxide or X-ray Irradiation},
 volume = {44},
 year = {2003}
}