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Nitric oxide-mediated bifunctional bystander effect induced by heavy-Ion Radiation in human salivary grand neoplastic cells
https://repo.qst.go.jp/records/43110
https://repo.qst.go.jp/records/43110cc8b38ce-1efc-4505-82ce-2971ff1e77d8
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2003-06-28 | |||||
| タイトル | ||||||
| タイトル | Nitric oxide-mediated bifunctional bystander effect induced by heavy-Ion Radiation in human salivary grand neoplastic cells | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Shao, Chunlin
× Shao, Chunlin× Furusawa, Yoshiya× Aoki, Mizuho× Matsumoto, Hideki× Ando, Koichi× Ｓｈａｏ Ｃｈｕｎｌｉｎ× 古澤 佳也× 青木 瑞穂× 松本 英樹× 安藤 興一 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Purpose: To investigate the signal factor and its function in the medium-mediated bystander effect during heavy-ion irradiation of human salivary gland (HSG) neoplastic cells. Materials and methods: Unirradiated recipient HSG cells were co-cultivated with HSG donor cells irradiated with 290 MeV/u carbon beams having different LET values. Cell proliferation and micronucleus (MN) induction in recipient cells with and without treatment of a NO scavenger (PTIO) were measured and the concentration of nitrite in the co-culture medium was detected. As a direct control, the effects of a nitric oxide (NO) generator (sper/NO) on cell proliferation and MN induction were also examined. Results: Increases in cell proliferation and MN induction were found in the recipient HSG cells as a result of co-culturing and cell proliferation was obviously enhanced during a further subculture. In comparison with 13 keV/um, 100 keV/um carbon-ion irradiation was found to be a more efficient inducer of the medium-mediated bystander effect. The treatment of cells by PTIO resulted in elimination of such effects, which supports a role for NO in the medium-mediated bystander effect. As an oxidization product of NO, nitrite was detected in the co-culture medium, and the dose-response for its concentration was similar to that of cell proliferation and MN induction in the recipient cells. When the HSG cells were treated by sper/NO with a concentration of less than 20 uM, cell proliferation was enhanced, whereas MN increased along with sper/NO concentration. Conclusion: NO participated in the medium-mediated bystander effects on cell proliferation and MN induction, depending on the LET of irradiation. | |||||
| 書誌情報 |
International Journal of Radiation Biology 巻 78, p. 837-844, 発行日 2002-09 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0955-3002 | |||||
