{"created":"2023-05-15T14:33:14.853513+00:00","id":43110,"links":{},"metadata":{"_buckets":{"deposit":"98ea58fd-d371-49da-b34c-25e8cb832b98"},"_deposit":{"created_by":1,"id":"43110","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"43110"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00043110","sets":["1"]},"author_link":["428921","428927","428926","428923","428920","428922","428918","428925","428919","428924"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2002-09","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"844","bibliographicPageStart":"837","bibliographicVolumeNumber":"78","bibliographic_titles":[{"bibliographic_title":"International Journal of Radiation Biology"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Purpose: To investigate the signal factor and its function in the medium-mediated bystander effect during heavy-ion irradiation of human salivary gland (HSG) neoplastic cells.   Materials and methods: Unirradiated recipient HSG cells were co-cultivated with HSG donor cells irradiated with 290 MeV/u carbon beams having different LET values. Cell proliferation and micronucleus (MN) induction in recipient cells with and without treatment of a NO scavenger (PTIO) were measured and the concentration of nitrite in the co-culture medium was detected. As a direct control, the effects of a nitric oxide (NO) generator (sper/NO) on cell proliferation and MN induction were also examined.    Results: Increases in cell proliferation and MN induction were found in the recipient HSG cells as a result of co-culturing and cell proliferation was obviously enhanced during a further subculture. In comparison with 13 keV/um, 100 keV/um carbon-ion irradiation was found to be a more efficient inducer of the medium-mediated bystander effect. The treatment of cells by PTIO resulted in elimination of such effects, which supports a role for NO in the medium-mediated bystander effect. As an oxidization product of NO, nitrite was detected in the co-culture medium, and the dose-response for its concentration was similar to that of cell proliferation and MN induction in the recipient cells. When the HSG cells were treated by sper/NO with a concentration of less than 20 uM, cell proliferation was enhanced, whereas MN increased along with sper/NO concentration.    Conclusion: NO participated in the medium-mediated bystander effects on cell proliferation and MN induction, depending on the LET of irradiation.","subitem_description_type":"Abstract"}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0955-3002","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Shao, Chunlin"}],"nameIdentifiers":[{"nameIdentifier":"428918","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Furusawa, Yoshiya"}],"nameIdentifiers":[{"nameIdentifier":"428919","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Aoki, Mizuho"}],"nameIdentifiers":[{"nameIdentifier":"428920","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Matsumoto, Hideki"}],"nameIdentifiers":[{"nameIdentifier":"428921","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ando, Koichi"}],"nameIdentifiers":[{"nameIdentifier":"428922","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ｓｈａｏ Ｃｈｕｎｌｉｎ","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"428923","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"古澤 佳也","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"428924","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"青木 瑞穂","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"428925","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"松本 英樹","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"428926","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"安藤 興一","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"428927","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Nitric oxide-mediated bifunctional bystander effect induced by heavy-Ion Radiation in human salivary grand neoplastic cells","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Nitric oxide-mediated bifunctional bystander effect induced by heavy-Ion Radiation in human salivary grand neoplastic cells"}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2003-06-28"},"publish_date":"2003-06-28","publish_status":"0","recid":"43110","relation_version_is_last":true,"title":["Nitric oxide-mediated bifunctional bystander effect induced by heavy-Ion Radiation in human salivary grand neoplastic cells"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-16T00:31:09.949482+00:00"}