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The enhancement of cell-killing effect irradiated with carbon-ion beams by applying longitudinal magnetic field relate to cellular response via gap-junction mediated cell-cell communication
https://repo.qst.go.jp/records/80635
https://repo.qst.go.jp/records/80635b24d9da4-374c-4a7f-bd0b-25fb3fe5b3ed
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2020-10-05 | |||||
| タイトル | ||||||
| タイトル | The enhancement of cell-killing effect irradiated with carbon-ion beams by applying longitudinal magnetic field relate to cellular response via gap-junction mediated cell-cell communication | |||||
| 言語 | ||||||
| 言語 | jpn | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
鈴木, 雅雄
× 鈴木, 雅雄× Suzuki, Masao |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | The last year we reported the enhancement of cell-killing effect irradiated with carbon ions by applying longitudinal magnetic field. This year we examined the mechanism of the effect, focusing on cellular response(s) via gap-junction mediated cell-cell communication. Normal human skin fibroblasts and cervical epitheloid carcinoma cells were irradiated with carbon ions (350MeV/n, LET~12keV/µm) accelerated with the Heavy Ion Medical Accelerator in Chiba under the longitudinal magnetic field (0.6T) with or without a specific inhibitor of gap junction (40 µM of gamma-isomer of hexachloro-cyclohexane). The cell-killing effects treated with the magnetic field were 1.3 ~ 1.5 times higher than those of carbon ion alone. When using the gap-junction inhibitor, the cell-killing effects were enhanced as the same level among the magnetic field alone, the gap-junction inhibitor alone and both treatments. There is evidence that the enhanced effect by the longitudinal magnetic fields is induced by cellular response(s) via gap-junction mediated cell-cell communication. (This is the co-operative study with Drs.T.Inaniwa, N.Usami, S.Sato, A.Noda, M.Muramatsu, Y.Iwata, N.Kanematsu, T.Shirai, K.Noda) | |||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 第79回日本癌学会学術総会 | |||||
| 発表年月日 | ||||||
| 日付 | 2020-10-01 | |||||
| 日付タイプ | Issued | |||||
