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An irradiation device for biological targets using focused microbeams of cyclotron-accelerated heavy ion
https://repo.qst.go.jp/records/78896
https://repo.qst.go.jp/records/788960713d1c7-131a-40b1-9b69-e16c56531dc0
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2020-01-07 | |||||
| タイトル | ||||||
| タイトル | An irradiation device for biological targets using focused microbeams of cyclotron-accelerated heavy ion | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Funayama, Tomoo
× Funayama, Tomoo× Sakashita, Tetsuya× Suzuki, Michiyo× Yokota, Yuichiro× Miyawaki, Nobumasa× Kashiwagi, Hirotsugu× Satoh, Takahiro× Kurashima, Satoshi× Tomo, Funayama× Tetsuya, Sakashita× Michiyo, Suzuki× Yuuichiro, Yokota× Nobumasa, Miyawaki× Hirotsugu, Kashiwagi× Takahiro, Satoh× Satoshi, Kurashima |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | For use in medical and life science research, a device and sample preparation methods were developed to irradiate cultured cells and individual animals with a focused microbeam of cyclotron-accelerated heavy-ions. The new irradiation device positions both sample and microscope with micrometer precision. The beam size is smaller than 3 μm when the distance between the beam exit from vacuum to the irradiation device is less than 500 μm for 13.0 MeV/n 20Ne ions. This beam size is sufficiently small to irradiate intracellular targets in cultured cells. A beam size smaller than 10 μm was obtained for 12C ions of 26.7 MeV/n at a distance of 2 mm from the beam exit, which enabled irradiation of specific cells in a small model animal. Methods to prepare cultured cells and the nematode Caenorhabditis elegans for irradiation using the new device are reported, and the results of the first irradiation experiments presented. | |||||
| 書誌情報 |
Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms 巻 465, p. 101-109, 発行日 2020-01 |
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| 出版者 | ||||||
| 出版者 | Elsevier | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0168-583X | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1016/j.nimb.2019.12.028 | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | https://www.sciencedirect.com/science/article/pii/S0168583X1930847X | |||||
