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RNA sequencing analysis of 211At-MABG treatment in PC12 pheochromocytoma cells
https://repo.qst.go.jp/records/74693
https://repo.qst.go.jp/records/7469374a448aa-eec4-409d-8038-9d88a4ab99a8
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2019-03-11 | |||||
| タイトル | ||||||
| タイトル | RNA sequencing analysis of 211At-MABG treatment in PC12 pheochromocytoma cells | |||||
| 言語 | ||||||
| 言語 | jpn | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
坂下, 哲哉
× 坂下, 哲哉× 大島, 康宏× 河野, 暢明× 横田, 裕一郎× 渡辺, 茂樹× 佐々木, 一郎× 石岡, 典子× 荒川, 和晴× Sakashita, Tetsuya× Oshima, Yasuhiro× Yokota, Yuuichiro× Watanabe, Shigeki× Sasaki, Ichiro× Ishioka, Noriko |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Sequencing empowers clinical diagnostics and therapy, but targeted alpha therapy has not yet fully received it. Recently, we observed strong anti-tumor effect of 211At-MABG in a pheochromocytoma mouse model. Here, we used RNA-sequencing to identify genes relevant to induced anti-tumor alpha-particle radiation response compared with 60Co γ-rays. The gene expression changes of PC12 cells were observed at 3, 6 and 12 h after 211At-MABG treatment and 60Co γ-rays irradiation, controlling dose of irradiation at survival levels of 10% and 80%. Minimum of 7 million reads were sequenced for each condition. Overall transcriptome profiles were strikingly distinct, but important gene expression changes of 10% survival for cell-cycle checkpoints finally reached the same level with a time delay. We now explore possible therapy or molecular imaging target genes for malignant pheochromocytoma. | |||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 第58回日本核医学会学術総会 | |||||
| 発表年月日 | ||||||
| 日付 | 2018-11-16 | |||||
| 日付タイプ | Issued | |||||
