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Adverse effects within 3 months of radiotherapy completion were graded using the National Cancer Institute Common Toxicity Criteria; high grade group were grade 3 or more (n = 180), low grade group were grade 1 or less (n = 180). Pooled genomic DNA (gDNA) (n = 90 from each group) was screened using 23,244 microsatellites. Markers with different inter-group frequencies (Fisher exact test P \u003c 0.05) were analyzed using the remaining pooled gDNA. Silencing RNA treatment was performed in cultured normal human skin fibroblasts.\n\\nResults\nForty-seven markers had positive association values; including one in the SEMA3A promoter region (P = 1.24 x10-5). SEMA3A knockdown enhanced radiation resistance.\n\\nConclusions\nThis study identified 47 putative radiosensitivity markers, and suggested a role for SEMA3A in radiosensitivity.", "subitem_description_type": "Abstract"}]}, "item_8_relation_14": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "10.1186/1471-2350-11-123", "subitem_relation_type_select": "DOI"}}]}, "item_8_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "1471-2350", "subitem_source_identifier_type": "ISSN"}]}, "item_access_right": {"attribute_name": "アクセス権", "attribute_value_mlt": [{"subitem_access_right": "metadata only access", "subitem_access_right_uri": "http://purl.org/coar/access_right/c_14cb"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Michikawa, Yuichi"}], "nameIdentifiers": [{"nameIdentifier": "478112", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Suga, Tomo"}], "nameIdentifiers": [{"nameIdentifier": "478113", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ishikawa, Atsuko"}], "nameIdentifiers": [{"nameIdentifier": "478114", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Hayashi, Hideki"}], "nameIdentifiers": [{"nameIdentifier": "478115", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Oka, Akira"}], "nameIdentifiers": [{"nameIdentifier": "478116", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Inoko, Hidetoshi"}], "nameIdentifiers": [{"nameIdentifier": "478117", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Iwakawa, Mayumi"}], "nameIdentifiers": [{"nameIdentifier": "478118", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Imai, Takashi"}], "nameIdentifiers": [{"nameIdentifier": "478119", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "道川 祐市", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "478120", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "菅 智", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "478121", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "石川 敦子", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "478122", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "岩川 眞由美", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "478123", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "今井 高志", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "478124", "nameIdentifierScheme": "WEKO"}]}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Genome wide screen identifies microsatellite markers associated with acute adverse effects following radiotherapy in cancer patients", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Genome wide screen identifies microsatellite markers associated with acute adverse effects following radiotherapy in cancer patients"}]}, "item_type_id": "8", "owner": "1", "path": ["1"], "permalink_uri": "https://repo.qst.go.jp/records/47662", "pubdate": {"attribute_name": "公開日", "attribute_value": "2017-03-15"}, "publish_date": "2017-03-15", "publish_status": "0", "recid": "47662", "relation": {}, "relation_version_is_last": true, "title": ["Genome wide screen identifies microsatellite markers associated with acute adverse effects following radiotherapy in cancer patients"], "weko_shared_id": -1}
Genome wide screen identifies microsatellite markers associated with acute adverse effects following radiotherapy in cancer patients
https://repo.qst.go.jp/records/47662
https://repo.qst.go.jp/records/476624c4659f0-e513-4b42-ada3-891eeb19f057
Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2017-03-15 | |||||
タイトル | ||||||
タイトル | Genome wide screen identifies microsatellite markers associated with acute adverse effects following radiotherapy in cancer patients | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
アクセス権 | ||||||
アクセス権 | metadata only access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
著者 |
Michikawa, Yuichi
× Michikawa, Yuichi× Suga, Tomo× Ishikawa, Atsuko× Hayashi, Hideki× Oka, Akira× Inoko, Hidetoshi× Iwakawa, Mayumi× Imai, Takashi× 道川 祐市× 菅 智× 石川 敦子× 岩川 眞由美× 今井 高志 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Background The response of normal tissues in cancer patients undergoing radiotherapy varies, possibly due to genetic differences underlying variation in radiosensitivity. \nMethods Cancer patients (n = 360) were selected retrospectively from the RadGenomics project. Adverse effects within 3 months of radiotherapy completion were graded using the National Cancer Institute Common Toxicity Criteria; high grade group were grade 3 or more (n = 180), low grade group were grade 1 or less (n = 180). Pooled genomic DNA (gDNA) (n = 90 from each group) was screened using 23,244 microsatellites. Markers with different inter-group frequencies (Fisher exact test P < 0.05) were analyzed using the remaining pooled gDNA. Silencing RNA treatment was performed in cultured normal human skin fibroblasts. \nResults Forty-seven markers had positive association values; including one in the SEMA3A promoter region (P = 1.24 x10-5). SEMA3A knockdown enhanced radiation resistance. \nConclusions This study identified 47 putative radiosensitivity markers, and suggested a role for SEMA3A in radiosensitivity. |
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書誌情報 |
BMC Medical Genetics (Online Only URL:http://www.biomedcentral.com/bmcmedgenet) 巻 11, 号 123, p. 123-1-123-11, 発行日 2010-08 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1471-2350 | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | 10.1186/1471-2350-11-123 |