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Methods: Human monolayer-type A172 glioblastoma cells were maintained in normal medium with 10% bovine serum. In order to obtain sphere-type A172 cells the medium was replaced with serum-free medium supplemented with growth factors. Both types of A172 cells were irradiated with either X-rays or carbon ion beams and their radiosensitivity was evaluated. Results: Serum-free medium induced expression of stem cell-related proteins in A172 cells along with the neurosphere-like appearance. These sphere-type cells were found resistant to both X-rays and carbon ion beams. Phosphorylation of histone H2A family member X persisted for a longer period in the cells exposed to carbon ion beams than in those exposed to X-rays and it disappeared quicker in the sphere type than in the monolayer type. Relative radioresistance of the sphere type cells was smaller for carbon ion beams than for X-rays. 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Accelerated heavy ion particles may have advantage over X-rays in overcoming the tumor resistance due to cell stemness.", "subitem_description_type": "Abstract"}]}, "item_8_publisher_8": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "Informa Healthcare"}]}, "item_8_relation_13": {"attribute_name": "PubMed番号", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "24882391", "subitem_relation_type_select": "PMID"}}]}, "item_8_relation_14": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "10.3109/09553002.2014.927933", "subitem_relation_type_select": "DOI"}}]}, "item_8_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "0955-3002", "subitem_source_identifier_type": "ISSN"}]}, "item_access_right": {"attribute_name": "アクセス権", "attribute_value_mlt": [{"subitem_access_right": "metadata only access", "subitem_access_right_uri": "http://purl.org/coar/access_right/c_14cb"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Takahashi, Momoko"}], "nameIdentifiers": [{"nameIdentifier": "469116", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Hirakawa, Hirokazu"}], "nameIdentifiers": [{"nameIdentifier": "469117", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Yajima, Hirohiko"}], "nameIdentifiers": [{"nameIdentifier": "469118", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Izumi-Nakajima, Nakako"}], "nameIdentifiers": [{"nameIdentifier": "469119", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Okayasu, Ryuichi"}], "nameIdentifiers": [{"nameIdentifier": "469120", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Fujimori, Akira"}], "nameIdentifiers": [{"nameIdentifier": "469121", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "平川 博一", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "469122", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "矢島 浩彦", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "469123", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "中島 菜花子", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "469124", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "岡安 隆一", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "469125", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "藤森 亮", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "469126", "nameIdentifierScheme": "WEKO"}]}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Carbon ion beam is more effective to induce cell death in sphere-type A172 human glioblastoma cells compared with X-rays.", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Carbon ion beam is more effective to induce cell death in sphere-type A172 human glioblastoma cells compared with X-rays."}]}, "item_type_id": "8", "owner": "1", "path": ["1"], "permalink_uri": "https://repo.qst.go.jp/records/46996", "pubdate": {"attribute_name": "公開日", "attribute_value": "2014-12-16"}, "publish_date": "2014-12-16", "publish_status": "0", "recid": "46996", "relation": {}, "relation_version_is_last": true, "title": ["Carbon ion beam is more effective to induce cell death in sphere-type A172 human glioblastoma cells compared with X-rays."], "weko_shared_id": -1}
Carbon ion beam is more effective to induce cell death in sphere-type A172 human glioblastoma cells compared with X-rays.
https://repo.qst.go.jp/records/46996
https://repo.qst.go.jp/records/4699689d93038-032e-4e68-8d59-32782e63fae3
Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2014-12-16 | |||||
タイトル | ||||||
タイトル | Carbon ion beam is more effective to induce cell death in sphere-type A172 human glioblastoma cells compared with X-rays. | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
アクセス権 | ||||||
アクセス権 | metadata only access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
著者 |
Takahashi, Momoko
× Takahashi, Momoko× Hirakawa, Hirokazu× Yajima, Hirohiko× Izumi-Nakajima, Nakako× Okayasu, Ryuichi× Fujimori, Akira× 平川 博一× 矢島 浩彦× 中島 菜花子× 岡安 隆一× 藤森 亮 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | Purpose: To obtain human glioblastoma cells A172 expressing stem cell-related protein and comparison of radiosensitivity in these cells with X-rays and carbon beam. Methods: Human monolayer-type A172 glioblastoma cells were maintained in normal medium with 10% bovine serum. In order to obtain sphere-type A172 cells the medium was replaced with serum-free medium supplemented with growth factors. Both types of A172 cells were irradiated with either X-rays or carbon ion beams and their radiosensitivity was evaluated. Results: Serum-free medium induced expression of stem cell-related proteins in A172 cells along with the neurosphere-like appearance. These sphere-type cells were found resistant to both X-rays and carbon ion beams. Phosphorylation of histone H2A family member X persisted for a longer period in the cells exposed to carbon ion beams than in those exposed to X-rays and it disappeared quicker in the sphere type than in the monolayer type. Relative radioresistance of the sphere type cells was smaller for carbon ion beams than for X-rays. Conclusions: We demonstrated that glioblastoma A172 cells with induced stem cell-related proteins turned resistant to irradiation. Accelerated heavy ion particles may have advantage over X-rays in overcoming the tumor resistance due to cell stemness. | |||||
書誌情報 |
International journal of radiation biology 巻 90, 号 12, p. 1125-1132, 発行日 2014-08 |
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出版者 | ||||||
出版者 | Informa Healthcare | |||||
ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 0955-3002 | |||||
PubMed番号 | ||||||
識別子タイプ | PMID | |||||
関連識別子 | 24882391 | |||||
DOI | ||||||
識別子タイプ | DOI | |||||
関連識別子 | 10.3109/09553002.2014.927933 |