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The purpose of\nthis study was to quantify changes to Mn2+ uptake in rat brain using a dynamic manganese-enhanced MRI\n(dMEMRI) scanning protocol with the Patlak and Logan graphical analysis methods. The graphical analysis\nwas based on a three-compartment model describing the tissue and plasma concentration of Mn. Mn2+\nuptake was characterized by the total distribution volume of manganese (Mn) inside tissue (VT) and the\nunidirectional influx constant of Mn2+ from plasma to tissue (Ki). The measurements were performed on\nthe anterior (APit) and posterior (PPit) parts of the pituitary gland, a region with an incomplete blood\nbrain barrier. Modulation of Ca2+ channel activity was performed by administration of the stimulant glutamate\nand the inhibitor verapamil. It was found that the APit and PPit showed different Mn2+ uptake characteristics.\nWhile the influx of Mn2+ into the PPit was reversible, Mn2+ was found to be irreversibly trapped in\nthe APit during the course of the experiment. In the PPit, an increase of Mn2+ uptake led to an increase in\nVT (from 2.8+-0.3 ml/cm3 to 4.6+-1.2 ml/cm3) while a decrease of Mn2+ uptake corresponded to a decrease\nin VT (from 2.8+-0.3 ml/cm3 to 1.4+-0.3 ml/cm3). In the APit, an increase of Mn2+ uptake led to an increase\nin Ki (from 0.034+-0.009 min\u0026#8722;1 to 0.049+-0.012 min\u0026#8722;1) while a decrease of Mn2+ uptake corresponded to a\ndecrease in Ki (from 0.034+-0.009 min\u0026#8722;1 to 0.019+-0.003 min\u0026#8722;1). This work demonstrates that graphical\nanalysis applied to dMEMRI data can quantitatively measure changes to Mn2+ uptake following modulation\nof neural activity.", "subitem_description_type": "Abstract"}]}, "item_8_relation_17": {"attribute_name": "関連サイト", "attribute_value_mlt": [{"subitem_relation_name": [{"subitem_relation_name_text": "http://dx.doi.org/10.1016/j.neuroimage.2011.12.030"}], "subitem_relation_type_id": {"subitem_relation_type_id_text": "http://dx.doi.org/10.1016/j.neuroimage.2011.12.030", "subitem_relation_type_select": "DOI"}}]}, "item_8_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "1053-8119", "subitem_source_identifier_type": "ISSN"}]}, "item_access_right": {"attribute_name": "アクセス権", "attribute_value_mlt": [{"subitem_access_right": "metadata only access", "subitem_access_right_uri": "http://purl.org/coar/access_right/c_14cb"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Leuze, Christoph"}], "nameIdentifiers": [{"nameIdentifier": "463726", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kimura, Yuichi"}], "nameIdentifiers": [{"nameIdentifier": "463727", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kershaw, Jeffrey"}], "nameIdentifiers": [{"nameIdentifier": "463728", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Shibata, Sayaka"}], "nameIdentifiers": [{"nameIdentifier": "463729", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Saga, Tsuneo"}], "nameIdentifiers": [{"nameIdentifier": "463730", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Aoki, Ichio"}], "nameIdentifiers": [{"nameIdentifier": "463731", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "et.al"}], "nameIdentifiers": [{"nameIdentifier": "463732", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "ロイツェ クリストフ", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "463733", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "木村 裕一", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "463734", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kershaw Jeffrey", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "463735", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "柴田 さやか", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "463736", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "佐賀 恒夫", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "463737", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "青木 伊知男", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "463738", "nameIdentifierScheme": "WEKO"}]}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Quantitative measurement of changes in calcium channel activity in vivo utilizing dynamic manganese-enhanced MRI (dMEMRI)", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Quantitative measurement of changes in calcium channel activity in vivo utilizing dynamic manganese-enhanced MRI (dMEMRI)"}]}, "item_type_id": "8", "owner": "1", "path": ["1"], "permalink_uri": "https://repo.qst.go.jp/records/46531", "pubdate": {"attribute_name": "公開日", "attribute_value": "2013-04-15"}, "publish_date": "2013-04-15", "publish_status": "0", "recid": "46531", "relation": {}, "relation_version_is_last": true, "title": ["Quantitative measurement of changes in calcium channel activity in vivo utilizing dynamic manganese-enhanced MRI (dMEMRI)"], "weko_shared_id": -1}
Quantitative measurement of changes in calcium channel activity in vivo utilizing dynamic manganese-enhanced MRI (dMEMRI)
https://repo.qst.go.jp/records/46531
https://repo.qst.go.jp/records/46531c78184d8-5ae9-4431-a434-0202422bb459
Item type | 学術雑誌論文 / Journal Article(1) | |||||
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公開日 | 2013-04-15 | |||||
タイトル | ||||||
タイトル | Quantitative measurement of changes in calcium channel activity in vivo utilizing dynamic manganese-enhanced MRI (dMEMRI) | |||||
言語 | ||||||
言語 | eng | |||||
資源タイプ | ||||||
資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
資源タイプ | journal article | |||||
アクセス権 | ||||||
アクセス権 | metadata only access | |||||
アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
著者 |
Leuze, Christoph
× Leuze, Christoph× Kimura, Yuichi× Kershaw, Jeffrey× Shibata, Sayaka× Saga, Tsuneo× Aoki, Ichio× et.al× ロイツェ クリストフ× 木村 裕一× Kershaw Jeffrey× 柴田 さやか× 佐賀 恒夫× 青木 伊知男 |
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抄録 | ||||||
内容記述タイプ | Abstract | |||||
内容記述 | The ability of manganese ions (Mn2+) to enter cells through calcium ion (Ca2+) channels has been used for depolarization dependent brain functional imaging with manganese-enhanced MRI (MEMRI). The purpose of this study was to quantify changes to Mn2+ uptake in rat brain using a dynamic manganese-enhanced MRI (dMEMRI) scanning protocol with the Patlak and Logan graphical analysis methods. The graphical analysis was based on a three-compartment model describing the tissue and plasma concentration of Mn. Mn2+ uptake was characterized by the total distribution volume of manganese (Mn) inside tissue (VT) and the unidirectional influx constant of Mn2+ from plasma to tissue (Ki). The measurements were performed on the anterior (APit) and posterior (PPit) parts of the pituitary gland, a region with an incomplete blood brain barrier. Modulation of Ca2+ channel activity was performed by administration of the stimulant glutamate and the inhibitor verapamil. It was found that the APit and PPit showed different Mn2+ uptake characteristics. While the influx of Mn2+ into the PPit was reversible, Mn2+ was found to be irreversibly trapped in the APit during the course of the experiment. In the PPit, an increase of Mn2+ uptake led to an increase in VT (from 2.8+-0.3 ml/cm3 to 4.6+-1.2 ml/cm3) while a decrease of Mn2+ uptake corresponded to a decrease in VT (from 2.8+-0.3 ml/cm3 to 1.4+-0.3 ml/cm3). In the APit, an increase of Mn2+ uptake led to an increase in Ki (from 0.034+-0.009 min−1 to 0.049+-0.012 min−1) while a decrease of Mn2+ uptake corresponded to a decrease in Ki (from 0.034+-0.009 min−1 to 0.019+-0.003 min−1). This work demonstrates that graphical analysis applied to dMEMRI data can quantitatively measure changes to Mn2+ uptake following modulation of neural activity. |
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書誌情報 |
NeuroImage 巻 60, 号 1, p. 392-399, 発行日 2011-12 |
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ISSN | ||||||
収録物識別子タイプ | ISSN | |||||
収録物識別子 | 1053-8119 | |||||
関連サイト | ||||||
識別子タイプ | DOI | |||||
関連識別子 | http://dx.doi.org/10.1016/j.neuroimage.2011.12.030 | |||||
関連名称 | http://dx.doi.org/10.1016/j.neuroimage.2011.12.030 |