{"created":"2023-05-15T14:36:08.878987+00:00","id":46531,"links":{},"metadata":{"_buckets":{"deposit":"0da8e908-b877-4427-87fe-70e4a3646aca"},"_deposit":{"created_by":1,"id":"46531","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"46531"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00046531","sets":["1"]},"author_link":["463729","463736","463728","463733","463737","463734","463732","463735","463730","463731","463727","463726","463738"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2011-12","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"399","bibliographicPageStart":"392","bibliographicVolumeNumber":"60","bibliographic_titles":[{"bibliographic_title":"NeuroImage"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The ability of manganese ions (Mn2+) to enter cells through calcium ion (Ca2+) channels has been used for\ndepolarization dependent brain functional imaging with manganese-enhanced MRI (MEMRI). The purpose of\nthis study was to quantify changes to Mn2+ uptake in rat brain using a dynamic manganese-enhanced MRI\n(dMEMRI) scanning protocol with the Patlak and Logan graphical analysis methods. The graphical analysis\nwas based on a three-compartment model describing the tissue and plasma concentration of Mn. Mn2+\nuptake was characterized by the total distribution volume of manganese (Mn) inside tissue (VT) and the\nunidirectional influx constant of Mn2+ from plasma to tissue (Ki). The measurements were performed on\nthe anterior (APit) and posterior (PPit) parts of the pituitary gland, a region with an incomplete blood\nbrain barrier. Modulation of Ca2+ channel activity was performed by administration of the stimulant glutamate\nand the inhibitor verapamil. It was found that the APit and PPit showed different Mn2+ uptake characteristics.\nWhile the influx of Mn2+ into the PPit was reversible, Mn2+ was found to be irreversibly trapped in\nthe APit during the course of the experiment. In the PPit, an increase of Mn2+ uptake led to an increase in\nVT (from 2.8+-0.3 ml/cm3 to 4.6+-1.2 ml/cm3) while a decrease of Mn2+ uptake corresponded to a decrease\nin VT (from 2.8+-0.3 ml/cm3 to 1.4+-0.3 ml/cm3). In the APit, an increase of Mn2+ uptake led to an increase\nin Ki (from 0.034+-0.009 min−1 to 0.049+-0.012 min−1) while a decrease of Mn2+ uptake corresponded to a\ndecrease in Ki (from 0.034+-0.009 min−1 to 0.019+-0.003 min−1). This work demonstrates that graphical\nanalysis applied to dMEMRI data can quantitatively measure changes to Mn2+ uptake following modulation\nof neural activity.","subitem_description_type":"Abstract"}]},"item_8_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_name":[{"subitem_relation_name_text":"http://dx.doi.org/10.1016/j.neuroimage.2011.12.030"}],"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://dx.doi.org/10.1016/j.neuroimage.2011.12.030","subitem_relation_type_select":"DOI"}}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1053-8119","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Leuze, Christoph"}],"nameIdentifiers":[{"nameIdentifier":"463726","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kimura, Yuichi"}],"nameIdentifiers":[{"nameIdentifier":"463727","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kershaw, Jeffrey"}],"nameIdentifiers":[{"nameIdentifier":"463728","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Shibata, Sayaka"}],"nameIdentifiers":[{"nameIdentifier":"463729","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Saga, Tsuneo"}],"nameIdentifiers":[{"nameIdentifier":"463730","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Aoki, Ichio"}],"nameIdentifiers":[{"nameIdentifier":"463731","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"et.al"}],"nameIdentifiers":[{"nameIdentifier":"463732","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"ロイツェ クリストフ","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"463733","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"木村 裕一","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"463734","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ｋｅｒｓｈａｗ Ｊｅｆｆｒｅｙ","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"463735","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"柴田 さやか","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"463736","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"佐賀 恒夫","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"463737","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"青木 伊知男","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"463738","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Quantitative measurement of changes in calcium channel activity in vivo utilizing dynamic manganese-enhanced MRI (dMEMRI)","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Quantitative measurement of changes in calcium channel activity in vivo utilizing dynamic manganese-enhanced MRI (dMEMRI)"}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2013-04-15"},"publish_date":"2013-04-15","publish_status":"0","recid":"46531","relation_version_is_last":true,"title":["Quantitative measurement of changes in calcium channel activity in vivo utilizing dynamic manganese-enhanced MRI (dMEMRI)"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T23:50:39.570830+00:00"}