Extrastriatal dopamine D2 receptor occupancy in olanzapine-treated patients with schizophrenia

Olanzapine is described as a multi-acting
receptor-targeted antipsychotic agent. Although regional
differences of dopamine D2 receptor occupancy, i.e., limbic
selectivity, were reported for olanzapine, contradictory
results were also reported. We measured dopamine D2
receptor occupancy of olanzapine in extrastriatal regions
in patients with schizophrenia using positron-emission
tomography with [11C]FLB457 and the plasma concentrations
of olanzapine. Ten patients with schizophrenia taking
5–20 mg/day of olanzapine participated. Dopamine D2
receptor occupancy in the temporal cortex ranged from
61.1 to 85.8%, and plasma concentration was from 12.7 to
115.4 ng/ml. The ED50 value was 3.4 mg/day for dose and
10.5 ng/ml for plasma concentration. The ED50 values
obtained in this study were quite similar to those previously
reported in the striatum. In conclusion, although the subjects
and methods were different from previous striatal
occupancy studies, these results suggest that limbic occupancy
by olanzapine may not be so different from that in
the striatum.

書誌情報

European Archives of Psychiatry and Clinical Neuroscience

巻 260, 号 4, p. 345-350, 発行日 2010-06

ISSN

収録物識別子タイプ

ISSN

収録物識別子

0940-1334

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