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Distribution volume as an alternative to the binding potential for sigma1receptor imaging
https://repo.qst.go.jp/records/45271
https://repo.qst.go.jp/records/452716baa54ee-4042-4f45-a41f-b48bec372a23
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2008-09-22 | |||||
| タイトル | ||||||
| タイトル | Distribution volume as an alternative to the binding potential for sigma1receptor imaging | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Kimura, Yuichi
× Kimura, Yuichi× Naganawa, Mika× Sakata, Muneyuki× Ishikawa, Masatomo× Mishina, Masahiro× Oda, Keiichi× Ishii, Kenji× Ishiwata, Kiichi× 木村 裕一× 長縄 美香× 織田 圭一× 石井 賢二× 石渡 喜一 |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | The applicability of total distribution volume (DVt) as an alternative to binding potential (BP) was investigated for neuroreceptor mapping by positron emission tomography (PET). BP is defi ned as a representative quantity of receptor density. However, for making parametric images of BP, a reference region where an aimed receptor has a very low density is assumed to exist in a target region such as the brain. Thus, if the kinetics of a radioligand for target receptors does not permit an appropriate reference region, BP imaging is unattainable. In this study, [11C]SA4503 PET is taken to be considered which has a high affi nity to the sigma1 receptors. Through a clinical investigation using wide ranges of physiological situations, ages, sex, diseases, and selective drug-loading conditions, DVt has a good linear relationship with BP, and the images can be used as a spatial stribution of sigma1 density. |
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| 書誌情報 |
Annals of Nuclear Medicine 巻 21, 号 9, p. 533-535, 発行日 2007-11 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0914-7187 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1007/s12149-007-0063-6 | |||||
