@article{oai:repo.qst.go.jp:00045271,
 author = {Kimura, Yuichi and Naganawa, Mika and Sakata, Muneyuki and Ishikawa, Masatomo and Mishina, Masahiro and Oda, Keiichi and Ishii, Kenji and Ishiwata, Kiichi and 木村 裕一 and 長縄 美香 and 織田 圭一 and 石井 賢二 and 石渡 喜一},
 issue = {9},
 journal = {Annals of Nuclear Medicine},
 month = {Nov},
 note = {The applicability of total distribution volume (DVt) as an alternative to binding potential (BP) was investigated for neuroreceptor mapping by positron emission tomography (PET). BP is defi ned as a representative quantity of receptor density. However, for making parametric images of BP, a reference region where an aimed receptor has a very low density is assumed to exist in a target region such as the brain. Thus, if the kinetics of a radioligand for target receptors does not permit an appropriate reference region, BP imaging is unattainable. In this study, [11C]SA4503 PET is taken to be considered which has a high affi nity to the sigma1 receptors. Through a clinical investigation using wide ranges of physiological situations, ages, sex, diseases, and selective drug-loading conditions, DVt has a
good linear relationship with BP, and the images can be used as a spatial stribution of sigma1 density.},
 pages = {533--535},
 title = {Distribution volume as an alternative to the binding potential for sigma1receptor imaging},
 volume = {21},
 year = {2007}
}