{"_buckets": {"deposit": "9d80b9ca-3ce8-4fe3-8b88-34e71d3fa7c5"}, "_deposit": {"created_by": 1, "id": "86471", "owners": [1], "pid": {"revision_id": 0, "type": "depid", "value": "86471"}, "status": "published"}, "_oai": {"id": "oai:repo.qst.go.jp:00086471", "sets": ["1"]}, "author_link": ["1058940", "1058966", "1058967", "1058960", "1058953", "1058955", "1058949", "1058962", "1058963", "1058952", "1058941", "1058968", "1058958", "1058946", "1058961", "1058948", "1058970", "1058947", "1058956", "1058957", "1058943", "1058950", "1058944", "1058942", "1058945", "1058954", "1058959", "1058951", "1058969", "1058964", "1058965"], "item_8_biblio_info_7": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2022-06", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "13", "bibliographicPageEnd": "9158", "bibliographicPageStart": "9144", "bibliographicVolumeNumber": "65", "bibliographic_titles": [{"bibliographic_title": "Journal of Medicinal Chemistry"}]}]}, "item_8_description_5": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "ABSTRACT: The transmembrane α-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid (AMPA) receptor regulatory protein γ-8 (TARP γ-8)\nconstitutes an auxiliary subunit of AMPA receptors, which mediates various\nbrain functions including learning and memory. TARP γ-8 has emerged as a\npromising therapeutic target for central nervous system disorders. Despite\nconsiderable efforts, previously reported TARP γ-8 PET radioligands, such as\n[\n11C]TARP-1903 and [11C]TARP-1811 series, were plagued by limited brain\nuptake and/or high nonspecific binding in vivo. Herein, we developed two\nnovel 11C-labeled probes, [11C]8 and [11C]15 (also named as [11C]TARP2105), of which the latter exhibited a reasonable brain uptake as well as\nspecific binding toward TARP γ-8 both in vitro and in vivo, as confirmed by\nblocking experiments with the commercially available TARP γ-8 inhibitor,\nJNJ-55511118 in the TARP γ-8-rich hippocampus. Overall, [11C]15 exhibited\npromising tracer characteristics and proved to be a lead positron-emission tomography ligand for the non-invasive quantification of\nTARP γ-8 in the mammalian brain.", "subitem_description_type": "Abstract"}]}, "item_8_publisher_8": {"attribute_name": "出版者", "attribute_value_mlt": [{"subitem_publisher": "American Chemical Society"}]}, "item_8_relation_14": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "10.1021/acs.jmedchem.2c00377", "subitem_relation_type_select": "DOI"}}]}, "item_8_relation_17": {"attribute_name": "関連サイト", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "https://doi.org/10.1021/acs.jmedchem.2c00377", "subitem_relation_type_select": "DOI"}}]}, "item_8_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "0022-2623", "subitem_source_identifier_type": "ISSN"}]}, "item_access_right": {"attribute_name": "アクセス権", "attribute_value_mlt": [{"subitem_access_right": "metadata only access", "subitem_access_right_uri": "http://purl.org/coar/access_right/c_14cb"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Qingzhen, Yu,"}], "nameIdentifiers": [{"nameIdentifier": "1058940", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Katsushi, Kumata"}], "nameIdentifiers": [{"nameIdentifier": "1058941", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Jian, Rong,"}], "nameIdentifiers": [{"nameIdentifier": "1058942", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Zhen, Chen,"}], "nameIdentifiers": [{"nameIdentifier": "1058943", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Tomoteru, Yamasaki"}], "nameIdentifiers": [{"nameIdentifier": "1058944", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Jiahui, Chen,"}], "nameIdentifiers": [{"nameIdentifier": "1058945", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Zhiwei, Xiao,"}], "nameIdentifiers": [{"nameIdentifier": "1058946", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Hideki, Ishii"}], "nameIdentifiers": [{"nameIdentifier": "1058947", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Atsuto, Hiraishi"}], "nameIdentifiers": [{"nameIdentifier": "1058948", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Tuo, Shao,"}], "nameIdentifiers": [{"nameIdentifier": "1058949", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Zhang, Yiding"}], "nameIdentifiers": [{"nameIdentifier": "1058950", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kuan, Hu"}], "nameIdentifiers": [{"nameIdentifier": "1058951", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Lin, Xie"}], "nameIdentifiers": [{"nameIdentifier": "1058952", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Masayuki, Fujinaga"}], "nameIdentifiers": [{"nameIdentifier": "1058953", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Chunyu, Zhao,"}], "nameIdentifiers": [{"nameIdentifier": "1058954", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Wakana, Mori"}], "nameIdentifiers": [{"nameIdentifier": "1058955", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Thomas, Collier,"}], "nameIdentifiers": [{"nameIdentifier": "1058956", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ahmed, Haider,"}], "nameIdentifiers": [{"nameIdentifier": "1058957", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Susumu, Tomita,"}], "nameIdentifiers": [{"nameIdentifier": "1058958", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Zhang, Ming-Rong"}], "nameIdentifiers": [{"nameIdentifier": "1058959", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Steven, Liang,"}], "nameIdentifiers": [{"nameIdentifier": "1058960", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Katsushi, Kumata", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "1058961", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Tomoteru, Yamasaki", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "1058962", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Hideki, Ishii", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "1058963", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Atsuto, Hiraishi", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "1058964", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Zhang, Yiding", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "1058965", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kuan, Hu", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "1058966", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Lin, Xie", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "1058967", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Masayuki, Fujinaga", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "1058968", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Wakana, Mori", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "1058969", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Zhang, Ming-Rong", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "1058970", "nameIdentifierScheme": "WEKO"}]}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Imaging of transmembrane AMPA receptor regulatory  protein by positron emission tomography", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Imaging of transmembrane AMPA receptor regulatory  protein by positron emission tomography"}]}, "item_type_id": "8", "owner": "1", "path": ["1"], "permalink_uri": "https://repo.qst.go.jp/records/86471", "pubdate": {"attribute_name": "公開日", "attribute_value": "2022-07-05"}, "publish_date": "2022-07-05", "publish_status": "0", "recid": "86471", "relation": {}, "relation_version_is_last": true, "title": ["Imaging of transmembrane AMPA receptor regulatory  protein by positron emission tomography"], "weko_shared_id": -1}