{"created":"2023-05-15T15:03:54.814277+00:00","id":86471,"links":{},"metadata":{"_buckets":{"deposit":"9d80b9ca-3ce8-4fe3-8b88-34e71d3fa7c5"},"_deposit":{"created_by":1,"id":"86471","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"86471"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00086471","sets":["1"]},"author_link":["1058940","1058966","1058967","1058960","1058953","1058955","1058949","1058962","1058963","1058952","1058941","1058968","1058958","1058946","1058961","1058948","1058970","1058947","1058956","1058957","1058943","1058950","1058944","1058942","1058945","1058954","1058959","1058951","1058969","1058964","1058965"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2022-06","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"13","bibliographicPageEnd":"9158","bibliographicPageStart":"9144","bibliographicVolumeNumber":"65","bibliographic_titles":[{"bibliographic_title":"Journal of Medicinal Chemistry"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"ABSTRACT: The transmembrane α-amino-3-hydroxyl-5-methyl-4-isoxazolepropionic acid (AMPA) receptor regulatory protein γ-8 (TARP γ-8)\nconstitutes an auxiliary subunit of AMPA receptors, which mediates various\nbrain functions including learning and memory. TARP γ-8 has emerged as a\npromising therapeutic target for central nervous system disorders. Despite\nconsiderable efforts, previously reported TARP γ-8 PET radioligands, such as\n[\n11C]TARP-1903 and [11C]TARP-1811 series, were plagued by limited brain\nuptake and/or high nonspecific binding in vivo. Herein, we developed two\nnovel 11C-labeled probes, [11C]8 and [11C]15 (also named as [11C]TARP2105), of which the latter exhibited a reasonable brain uptake as well as\nspecific binding toward TARP γ-8 both in vitro and in vivo, as confirmed by\nblocking experiments with the commercially available TARP γ-8 inhibitor,\nJNJ-55511118 in the TARP γ-8-rich hippocampus. Overall, [11C]15 exhibited\npromising tracer characteristics and proved to be a lead positron-emission tomography ligand for the non-invasive quantification of\nTARP γ-8 in the mammalian brain.","subitem_description_type":"Abstract"}]},"item_8_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"American Chemical Society"}]},"item_8_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1021/acs.jmedchem.2c00377","subitem_relation_type_select":"DOI"}}]},"item_8_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1021/acs.jmedchem.2c00377","subitem_relation_type_select":"DOI"}}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0022-2623","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Qingzhen, Yu,"}],"nameIdentifiers":[{"nameIdentifier":"1058940","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Katsushi, Kumata"}],"nameIdentifiers":[{"nameIdentifier":"1058941","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Jian, Rong,"}],"nameIdentifiers":[{"nameIdentifier":"1058942","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Zhen, Chen,"}],"nameIdentifiers":[{"nameIdentifier":"1058943","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tomoteru, Yamasaki"}],"nameIdentifiers":[{"nameIdentifier":"1058944","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Jiahui, Chen,"}],"nameIdentifiers":[{"nameIdentifier":"1058945","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Zhiwei, Xiao,"}],"nameIdentifiers":[{"nameIdentifier":"1058946","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hideki, Ishii"}],"nameIdentifiers":[{"nameIdentifier":"1058947","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Atsuto, Hiraishi"}],"nameIdentifiers":[{"nameIdentifier":"1058948","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tuo, Shao,"}],"nameIdentifiers":[{"nameIdentifier":"1058949","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Zhang, Yiding"}],"nameIdentifiers":[{"nameIdentifier":"1058950","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kuan, Hu"}],"nameIdentifiers":[{"nameIdentifier":"1058951","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Lin, Xie"}],"nameIdentifiers":[{"nameIdentifier":"1058952","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Masayuki, Fujinaga"}],"nameIdentifiers":[{"nameIdentifier":"1058953","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Chunyu, Zhao,"}],"nameIdentifiers":[{"nameIdentifier":"1058954","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Wakana, Mori"}],"nameIdentifiers":[{"nameIdentifier":"1058955","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Thomas, Collier,"}],"nameIdentifiers":[{"nameIdentifier":"1058956","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ahmed, Haider,"}],"nameIdentifiers":[{"nameIdentifier":"1058957","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Susumu, Tomita,"}],"nameIdentifiers":[{"nameIdentifier":"1058958","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Zhang, Ming-Rong"}],"nameIdentifiers":[{"nameIdentifier":"1058959","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Steven, Liang,"}],"nameIdentifiers":[{"nameIdentifier":"1058960","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Katsushi, Kumata","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1058961","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tomoteru, Yamasaki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1058962","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hideki, Ishii","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1058963","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Atsuto, Hiraishi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1058964","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Zhang, Yiding","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1058965","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kuan, Hu","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1058966","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Lin, Xie","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1058967","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Masayuki, Fujinaga","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1058968","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Wakana, Mori","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1058969","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Zhang, Ming-Rong","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1058970","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Imaging of transmembrane AMPA receptor regulatory  protein by positron emission tomography","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Imaging of transmembrane AMPA receptor regulatory  protein by positron emission tomography"}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2022-07-05"},"publish_date":"2022-07-05","publish_status":"0","recid":"86471","relation_version_is_last":true,"title":["Imaging of transmembrane AMPA receptor regulatory  protein by positron emission tomography"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T16:50:20.307416+00:00"}