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Building a Coarse-grained Model of Chromatin: Nucleosome-Nucleosome Interaction Patterns.
https://repo.qst.go.jp/records/86317
https://repo.qst.go.jp/records/86317f793e69b-747e-465b-9000-0e4a7ac19969
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2022-05-23 | |||||
| タイトル | ||||||
| タイトル | Building a Coarse-grained Model of Chromatin: Nucleosome-Nucleosome Interaction Patterns. | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Soon Chan, Wai
× Soon Chan, Wai× Hidetoshi, Kono× Soon Chan, Wai× Hidetoshi, Kono |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Epigenetics play an important role in regulating gene expression in cells. Nucleosomes which are a complex of histone proteins-DNA, which are involved in DNA packing, are the most common protein-DNA complexes in the eukaryotic genome. Post-translational modifications (PTMs) of nucleosome’s histones can affect the interactions between nucleosomes thus affecting the underlying expression of genes that are wrapped within the nucleosomes. Although experimental data of contact frequency maps between nucleosomes (Micro-C XL) and the locations of the PTMs (ChIP-seq) are available, we lack a method to disentangle the effects of PTMs on chromatin structure. We propose to build a coarse-grained model that can capture the effects of PTMs on the packing of nucleosomes or chromatin structure. As part of building this model, we first cleaned and analyzed the Micro-C XL dataset. Here we will share the analysis and insights obtained from this dataset. | |||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 量子生命科学会 第4回大会 | |||||
| 発表年月日 | ||||||
| 日付 | 2022-05-26 | |||||
| 日付タイプ | Issued | |||||
