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Multifunctional Magnetic CuS/Gd2O3 Nanoparticles for Fluorescence/MR Bimodal Imaging-guided Photothermal-intensified Chemodynamic Synergetic Therapy of Targeted Tumors
https://repo.qst.go.jp/records/86241
https://repo.qst.go.jp/records/86241a2536907-6a82-4d89-8b40-46430b36f729
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2022-06-02 | |||||
| タイトル | ||||||
| タイトル | Multifunctional Magnetic CuS/Gd2O3 Nanoparticles for Fluorescence/MR Bimodal Imaging-guided Photothermal-intensified Chemodynamic Synergetic Therapy of Targeted Tumors | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Minchuan, Luo
× Minchuan, Luo× Daisuke, Onoshima× Hiroshi, Yukawa× Yoshinobu, Baba× Hiroshi, Yukawa× Yoshinobu, Baba |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Chemodynamic therapy (CDT) that generate reactive oxygen species (ROS) and causes oxidative damage to tumor cells shows tremendous promise for advanced cancer treatment. Herein, we report a multifunctional nanoprobe (BCGCR) integrating bimodal imaging and photothermal-enhanced CDT of targeted tumor, which is produced by covalent conjugation of bovine serum albumin-stabilized CuS/Gd2O3 nanoparticles with Cy5.5 fluorophore and tumor-targeting ligand RGD. It was used for both sensitive fluorescence imaging and high-spatial-resolution magnetic resonance imaging of tumor in vivo. Moreover, owing to the strong NIR absorbance from internal CuS NPs, BCGCR can generate localized heat under 980nm laser irradiation, which enables photothermal therapy (PTT) and further intensifies ROS generation for enhanced CDT. This synergetic effect takes on such an excellent therapeutic efficacy that it can ablate xenografted tumors in vivo. | |||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 第16回日本分子イメージング学会総会・学術集会 | |||||
| 発表年月日 | ||||||
| 日付 | 2022-05-27 | |||||
| 日付タイプ | Issued | |||||
