@misc{oai:repo.qst.go.jp:00086241,
 author = {Minchuan, Luo and Daisuke, Onoshima and Hiroshi, Yukawa and Yoshinobu, Baba and Hiroshi, Yukawa and Yoshinobu, Baba},
 month = {May},
 note = {Chemodynamic therapy (CDT) that generate reactive oxygen species (ROS) and causes oxidative damage to tumor cells shows tremendous promise for advanced cancer treatment. Herein, we report a multifunctional nanoprobe (BCGCR) integrating bimodal imaging and photothermal-enhanced CDT of　targeted tumor, which is produced by covalent conjugation of bovine serum albumin-stabilized CuS/Gd2O3 nanoparticles with Cy5.5 fluorophore and tumor-targeting ligand RGD. It was used for both sensitive fluorescence imaging and high-spatial-resolution magnetic resonance imaging of tumor in vivo. Moreover, owing to the strong NIR absorbance from internal CuS NPs, BCGCR can generate localized heat under 980nm laser irradiation, which enables photothermal therapy (PTT) and further intensifies ROS generation for enhanced CDT. This synergetic effect takes on such an excellent therapeutic efficacy that it can ablate xenografted tumors in vivo., 第16回日本分子イメージング学会総会・学術集会},
 title = {Multifunctional Magnetic CuS/Gd2O3 Nanoparticles for Fluorescence/MR Bimodal  Imaging-guided Photothermal-intensified Chemodynamic Synergetic Therapy of  Targeted Tumors},
 year = {2022}
}