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Glutamatergic dysfunction associated with tau depositions in Alzheimer’s disease
https://repo.qst.go.jp/records/86091
https://repo.qst.go.jp/records/8609161da2161-13d6-44c3-9a43-3c099d78ab83
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2022-05-10 | |||||
| タイトル | ||||||
| タイトル | Glutamatergic dysfunction associated with tau depositions in Alzheimer’s disease | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Kiwamu, Matsuoka
× Kiwamu, Matsuoka× Kosei, Hirata× Naomi, Kokubo× Kenji, Tagai× Hironobu, Endo× Keisuke, Takahata× Hitoshi, Shinoto× Maiko, Ono× Chie, Seki× Kazunori, Kawamura× Zhang, Ming-Rong× Hitoshi, Shimada× Yuhei, Takado× Makoto, Higuchi× Kiwamu, Matsuoka× Kosei, Hirata× Naomi, Kokubo× Kenji, Tagai× Hironobu, Endo× Keisuke, Takahata× Hitoshi, Shinoto× Maiko, Ono× Chie, Seki× Kazunori, Kawamura× Zhang, Ming-Rong× Hitoshi, Shimada× Yuhei, Takado× Makoto, Higuchi |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Glutamatergic neurons and cingulate cortices have crucial roles in the cognitive dysfunction of Alzheimer's disease (AD). This study aimed to evaluate regional vulnerabilities of the glutamatergic system in AD at the level of the cingulate gyrus in relation to tau and amyloid-β (Aβ) depositions. Combining MRSI and PET, we found that the glutamatergic system in the posterior cingulate cortex (PCC) is vulnerable to tau deposits but not Aβ from the early stage of AD, and glutamate in the PCC region may be a marker of disease progression in AD. | |||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 2022 Joint Annual Meeting ISMRM-ESMRMB | |||||
| 発表年月日 | ||||||
| 日付 | 2022-05-09 | |||||
| 日付タイプ | Issued | |||||
