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Multicenter study of re-irradiation using carbon-ions for head and neck malignancies after photon radiotherapy.
https://repo.qst.go.jp/records/85992
https://repo.qst.go.jp/records/8599254de1146-448d-4628-adde-02de8f3d8630
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2022-04-15 | |||||
| タイトル | ||||||
| タイトル | Multicenter study of re-irradiation using carbon-ions for head and neck malignancies after photon radiotherapy. | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Takahashi, Daiki
× Takahashi, Daiki× Demizu, Yusuke× Koto, Masashi× Kubo, Nobuteru× Suefuji, Hiroaki× Ikawa, Hiroaki× Ohno, Tatsuya× Shioyama, Yoshiyuki× Okimoto, Tomoaki× Tsuji, Hiroshi× Daiki, Takahashi× Masashi, Koto× Nobuteru, Kubo× Hiroaki, Suefuji× Hiroaki, Ikawa× Tatsuya, Ohno× Yoshiyuki, Shioyama× Tomoaki, Okimoto× Hiroshi, Tsuji |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Purpose: The goal of this multicenter retrospective study of patients with head and neck malignancies was to evaluate the efficacy and safety of carbon-ion (C-ion) radiotherapy (RT) after photon RT. Methods: We enrolled 56 patients with head and neck malignancies who underwent re-irradiation (re-RT) using C-ions between November 2003 and March 2019, treated previously with photon RT. The tumors at re-RT were located in the sinonasal cavities (n = 20, 35.7%), skull base (n = 12, 21.4%), and orbit (n = 7, 12.5%). The tumors at the initial RT were located in the sinonasal cavities (n = 13, 23.2%), skull base (n = 9, 16.1%), and orbit (n = 9, 16.1%). The median period between the initial RT and re-RT was 41 (4-568) months. The most common histology of re-RT was squamous cell carcinoma (n = 11, 19.6%). The most commonly used protocol was 57.6 Gy (relative biological effectiveness) in 16 fractions (n = 23, 41.1%). Surgery preceded re-RT in three patients (5.4%). One patient with malignant melanoma received concurrent chemotherapy. Results: The 2-year local control, progression-free survival, and overall survival rates were 66.5%, 36.9%, and 67.9%, respectively. The median follow-up time was 28 months. Two patients (3.6%) developed grade ≥ 3 acute toxicities, and 14 (25.0%) developed grade ≥ 3 late toxicities. A single patient had confirmed grade 5 dermatitis with infection. Conclusion: Re-RT using C-ions for head and neck malignancies after photon RT is an effective treatment with tolerable toxicity. |
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| 書誌情報 |
Cancer medicine 発行日 2022-01 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 2045-7634 | |||||
| PubMed番号 | ||||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 35393701 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1002/cam4.4741 | |||||
