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Enhanced effects of chronic restraint-induced psychological stress on total body Fe-irradiation-induced hematopoietic toxicity in Trp53-heterozygous mice
https://repo.qst.go.jp/records/85986
https://repo.qst.go.jp/records/85986dcd31f1c-eb39-47b6-b157-9077d8119a72
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2022-04-12 | |||||
| タイトル | ||||||
| タイトル | Enhanced effects of chronic restraint-induced psychological stress on total body Fe-irradiation-induced hematopoietic toxicity in Trp53-heterozygous mice | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Bing, Wang
× Bing, Wang× Takanori, Katsube× Kaoru, Tanaka× Yasuharu, Ninomiya× Hirokazu, Hirakawa× Liu, Cuihua× Kouichi, Maruyama× Guillaume, Varès× Seiji, Kito× Tetsuo, Nakajima× Akira, Fujimori× Mitsuru, Nenoi× Bing, Wang× Takanori, Katsube× Kaoru, Tanaka× Yasuharu, Ninomiya× Hirokazu, Hirakawa× Liu, Cuihua× Kouichi, Maruyama× Seiji, Kito× Tetsuo, Nakajima× Akira, Fujimori× Mitsuru, Nenoi |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Humans would be exposed to both psychological stress (PS) and radiation in some scenarios such as manned deep-space missions and radiotherapy. It is of great concern to verify possible enhanced deleterious effects from such concurrent exposure. Pioneer studies showed that chronic restraint-induced PS (CRIPS) could attenuate Trp53 functions and increase gamma-ray-induced carcinogenesis in Trp53-heterozygous mice while CRIPS did not significantly modify the effects on X-ray-induced hematopoietic toxicity in Trp53 wild-type mice. As high-linear energy transfer (LET) radiation is the most important component of space radiation in causing biological effects and is practically applied in hadrontherapy, we further investigated the effects of CRIPS on high-LET iron-particle radiation (Fe)-induced hematopoietic toxicity in Trp53-heterozygous mice. Results showed that CRIPS alone could hardly induce significant alteration in hematological parameters (peripheral hemogram and micronucleated erythrocytes in bone marrow) while Fe alone could lead to significant alteration. Meanwhile, concurrent exposure always caused elevated micronucleated incidence. The incidence was significantly higher in animals exposed to both CRIPS and 0.1 Gy Fe compared to that in animals exposed to 0.1 Gy Fe alone. These findings indicated that CRIPS could enhance the deleterious effects of high-LET radiation, particularly at a low dose, on the hematopoietic toxicity in Trp53-heterozygous mice. Keywords: chronic restraint-induced stress; total-body irradiation; iron-particle radiation; peripheral hemogram; bone marrow micronucleated erythrocytes; mouse restraint model |
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| 書誌情報 |
Life 巻 12, 号 4, p. 565, 発行日 2022-04 |
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| 出版者 | ||||||
| 出版者 | MDPI AG | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 2075-1729 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.3390/life12040565 | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | https://www.mdpi.com/2075-1729/12/4/565 | |||||
