@article{oai:repo.qst.go.jp:00085986,
 author = {Bing, Wang and Takanori, Katsube and Kaoru, Tanaka and Yasuharu, Ninomiya and Hirokazu, Hirakawa and Liu, Cuihua and Kouichi, Maruyama and Guillaume, Varès and Seiji, Kito and Tetsuo, Nakajima and Akira, Fujimori and Mitsuru, Nenoi and Bing, Wang and Takanori, Katsube and Kaoru, Tanaka and Yasuharu, Ninomiya and Hirokazu, Hirakawa and Liu, Cuihua and Kouichi, Maruyama and Seiji, Kito and Tetsuo, Nakajima and Akira, Fujimori and Mitsuru, Nenoi},
 issue = {4},
 journal = {Life},
 month = {Apr},
 note = {Humans would be exposed to both psychological stress (PS) and radiation in some scenarios such as manned deep-space missions and radiotherapy. It is of great concern to verify possible enhanced deleterious effects from such concurrent exposure. Pioneer studies showed that chronic restraint-induced PS (CRIPS) could attenuate Trp53 functions and increase gamma-ray-induced carcinogenesis in Trp53-heterozygous mice while CRIPS did not significantly modify the effects on X-ray-induced hematopoietic toxicity in Trp53 wild-type mice. As high-linear energy transfer (LET) radiation is the most important component of space radiation in causing biological effects and is practically applied in hadrontherapy, we further investigated the effects of CRIPS on high-LET iron-particle radiation (Fe)-induced hematopoietic toxicity in Trp53-heterozygous mice. Results showed that CRIPS alone could hardly induce significant alteration in hematological parameters (peripheral hemogram and micronucleated erythrocytes in bone marrow) while Fe alone could lead to significant alteration. Meanwhile, concurrent exposure always caused elevated micronucleated incidence. The incidence was significantly higher in animals exposed to both CRIPS and 0.1 Gy Fe compared to that in animals exposed to 0.1 Gy Fe alone. These findings indicated that CRIPS could enhance the deleterious effects of high-LET radiation, particularly at a low dose, on the hematopoietic toxicity in Trp53-heterozygous mice.

Keywords: chronic restraint-induced stress; total-body irradiation; iron-particle radiation; peripheral hemogram; bone marrow micronucleated erythrocytes; mouse restraint model},
 title = {Enhanced effects of chronic restraint-induced psychological stress on total body Fe-irradiation-induced hematopoietic toxicity in Trp53-heterozygous mice},
 volume = {12},
 year = {2022}
}