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Histone deacetylation regulates nucleotide excision repair through an interaction with the XPC protein
https://repo.qst.go.jp/records/85863
https://repo.qst.go.jp/records/858637ee1972c-9e33-47af-a43c-879ee5b3057f
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2022-04-05 | |||||
| タイトル | ||||||
| タイトル | Histone deacetylation regulates nucleotide excision repair through an interaction with the XPC protein | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Kusakabe, Masayuki
× Kusakabe, Masayuki× Kakumu, Erina× Kurihara, Fumika× Tsuchida, Kazuki× Maeda, Takumi× Tada, Haruto× Kusao, Kanako× Kato, Akari× Takeshi, Yasuda× Matsuda, Tomonari× Nakao, Mitsuyoshi× Yokoi, Masayuki× Sakai, Wataru× Sugasawa, Kaoru× Takeshi, Yasuda |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | The XPC protein complex plays a central role in DNA lesion recognition for global genome nucleotide excision repair (GG-NER). Lesion recognition can be accomplished in either a UV-DDB-dependent or -independent manner; however, it is unclear how these sub-pathways are regulated in chromatin. Here, we show that histone deacetylases 1 and 2 facilitate UV-DDB-independent recruitment of XPC to DNA damage by inducing histone deacetylation. XPC localizes to hypoacetylated chromatin domains in a DNA damage-independent manner, mediated by its structurally disordered middle (M) region. TheMregion interacts directly with the N-terminal tail of histone H3, an interaction compromised by H3 acetylation. Although the M region is dispensable for in vitro NER, it promotes DNA damage removal by GG-NER in vivo, particularly in the absence of UV-DDB. We propose that histone deacetylation around DNA damage facilitates the recruitment of XPC through the M region, contributing to efficient lesion recognition and initiation of GG-NER. | |||||
| 書誌情報 |
iScience 巻 25, 号 14, p. 104040, 発行日 2022-04 |
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| 出版者 | ||||||
| 出版者 | Cell Press | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 2589-0042 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1016/j.isci.2022.104040 | |||||
| 関連サイト | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | https://doi.org/10.1016/j.isci.2022.104040 | |||||
