{"created":"2023-05-15T15:03:23.102569+00:00","id":85863,"links":{},"metadata":{"_buckets":{"deposit":"01a17d0d-6e08-4c7f-a37d-b4dba5c1f71a"},"_deposit":{"created_by":1,"id":"85863","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"85863"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00085863","sets":["1"]},"author_link":["1042753","1042744","1042743","1042755","1042749","1042756","1042757","1042745","1042754","1042746","1042752","1042751","1042750","1042747","1042748"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2022-04","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"14","bibliographicPageStart":"104040","bibliographicVolumeNumber":"25","bibliographic_titles":[{"bibliographic_title":"iScience"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The XPC protein complex plays a central role in DNA lesion recognition for global genome nucleotide excision repair (GG-NER). Lesion recognition can be　accomplished in either a UV-DDB-dependent or -independent manner; however, it is unclear how these sub-pathways are regulated in chromatin. Here, we show　that histone deacetylases 1 and 2 facilitate UV-DDB-independent recruitment of XPC to DNA damage by inducing histone deacetylation. XPC localizes to hypoacetylated chromatin domains in a DNA damage-independent manner, mediated by its structurally disordered middle (M) region. TheMregion interacts directly with the N-terminal tail of histone H3, an interaction compromised by H3 acetylation. Although the M region is dispensable for in vitro NER, it promotes DNA damage removal by GG-NER in vivo, particularly in the absence of UV-DDB. We propose that histone deacetylation around DNA damage facilitates the recruitment of XPC through the M region, contributing to efficient lesion recognition and initiation of GG-NER.","subitem_description_type":"Abstract"}]},"item_8_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Cell Press"}]},"item_8_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1016/j.isci.2022.104040","subitem_relation_type_select":"DOI"}}]},"item_8_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://doi.org/10.1016/j.isci.2022.104040","subitem_relation_type_select":"DOI"}}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"2589-0042","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Kusakabe, Masayuki"}],"nameIdentifiers":[{"nameIdentifier":"1042743","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kakumu, Erina"}],"nameIdentifiers":[{"nameIdentifier":"1042744","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kurihara, Fumika"}],"nameIdentifiers":[{"nameIdentifier":"1042745","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tsuchida, Kazuki"}],"nameIdentifiers":[{"nameIdentifier":"1042746","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Maeda, Takumi"}],"nameIdentifiers":[{"nameIdentifier":"1042747","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tada, Haruto"}],"nameIdentifiers":[{"nameIdentifier":"1042748","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kusao, Kanako"}],"nameIdentifiers":[{"nameIdentifier":"1042749","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kato, Akari"}],"nameIdentifiers":[{"nameIdentifier":"1042750","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Takeshi, Yasuda"}],"nameIdentifiers":[{"nameIdentifier":"1042751","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Matsuda, Tomonari"}],"nameIdentifiers":[{"nameIdentifier":"1042752","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nakao, Mitsuyoshi"}],"nameIdentifiers":[{"nameIdentifier":"1042753","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yokoi, Masayuki"}],"nameIdentifiers":[{"nameIdentifier":"1042754","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Sakai, Wataru"}],"nameIdentifiers":[{"nameIdentifier":"1042755","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Sugasawa, Kaoru"}],"nameIdentifiers":[{"nameIdentifier":"1042756","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Takeshi, Yasuda","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1042757","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Histone deacetylation regulates nucleotide excision repair through an interaction with the XPC protein","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Histone deacetylation regulates nucleotide excision repair through an interaction with the XPC protein"}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2022-04-05"},"publish_date":"2022-04-05","publish_status":"0","recid":"85863","relation_version_is_last":true,"title":["Histone deacetylation regulates nucleotide excision repair through an interaction with the XPC protein"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T17:21:10.220797+00:00"}