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Testis-ova Induction by Microbeam Irradiation in P53-Deficient Medaka Testis
https://repo.qst.go.jp/records/85748
https://repo.qst.go.jp/records/85748c794f710-4b22-4ce1-84eb-8566c4994847
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2021-09-14 | |||||
| タイトル | ||||||
| タイトル | Testis-ova Induction by Microbeam Irradiation in P53-Deficient Medaka Testis | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Nagata, Kento
× Nagata, Kento× Yasuda, Takako× Suzuki, Michiyo× Funayama, Tomoo× Mitani, Hiroshi× Oda, Shoji× Kento, Nagata× Michiyo, Suzuki× Tomo, Funayama |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | The Japanese medaka, Oryzias latipes, is a small teleost fish that has been used as a model organism to investigate the biological effects of radiation in vertebrates. A testis–ova can be differentiated in medaka testis lacking the p53 gene when exposed to gamma-ray radiation. To explore whether the differentiation of medaka testis–ova by radiation is mediated by increased serum estrogen levels, local irradiation of medaka testis was carried out using heavy-ion microbeam of QST-Takasaki. Experimental result revealed that a cluster of testis-ova cells with enlarged nucleoplasm and condensed nucleoli in a cyst of spermatogonia presumably located in the path of the microbeam at 7 days after the targeted irradiation by carbon ions. This suggests that radiation-inducible hormonal signaling might not be involved in testis-ova formation. Our findings will become a help to understand the effects of radiotherapy and chemotherapy on reproductive stem cell differentiation. |
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| 書誌情報 |
Cytologia 巻 87, 号 1, p. 1-2, 発行日 2022-03 |
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| 出版者 | ||||||
| 出版者 | The Japan Mendel Society | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0011-4545 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1508/cytologia.87.1 | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | https://www.jstage.jst.go.jp/article/cytologia/87/1/87_870103/_article | |||||
