@article{oai:repo.qst.go.jp:00085748,
 author = {Nagata, Kento and Yasuda, Takako and Suzuki, Michiyo and Funayama, Tomoo and Mitani, Hiroshi and Oda, Shoji and Kento, Nagata and Michiyo, Suzuki and Tomo, Funayama},
 issue = {1},
 journal = {Cytologia},
 month = {Mar},
 note = {The Japanese medaka, Oryzias latipes, is a small teleost fish that has been used as a model organism to investigate the biological effects of radiation in vertebrates. A testis–ova can be differentiated in medaka testis lacking the p53 gene when exposed to gamma-ray radiation. To explore whether the differentiation of medaka testis–ova by radiation is mediated by increased serum estrogen levels, local irradiation of medaka testis was carried out using heavy-ion microbeam of QST-Takasaki. 
Experimental result revealed that a cluster of testis-ova cells with enlarged nucleoplasm and condensed nucleoli in a cyst of spermatogonia presumably located in the path of the microbeam at 7 days after the targeted irradiation by carbon ions. This suggests that radiation-inducible hormonal signaling might not be involved in testis-ova formation. Our findings will become a help to understand the effects of radiotherapy and chemotherapy on reproductive stem cell differentiation.},
 pages = {1--2},
 title = {Testis-ova Induction by Microbeam Irradiation in P53-Deficient Medaka Testis},
 volume = {87},
 year = {2022}
}