ログイン
言語:

WEKO3

  • トップ
  • ランキング
To
lat lon distance
To

Field does not validate



インデックスリンク

インデックスツリー

メールアドレスを入力してください。

WEKO

One fine body…

WEKO

One fine body…

アイテム

  1. 原著論文

Environmental Enrichment Increases Radiation-induced Apoptosis Not Spontaneous Apoptosis in Mouse Intestinal Crypt Cells

https://repo.qst.go.jp/records/85654
https://repo.qst.go.jp/records/85654
8550dc8c-0732-4149-b61e-ab21b68086b3
Item type 学術雑誌論文 / Journal Article(1)
公開日 2021-10-11
タイトル
タイトル Environmental Enrichment Increases Radiation-induced Apoptosis Not Spontaneous Apoptosis in Mouse Intestinal Crypt Cells
言語
言語 eng
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
アクセス権
アクセス権 metadata only access
アクセス権URI http://purl.org/coar/access_right/c_14cb
著者 Shinya, Yokomizo

× Shinya, Yokomizo

WEKO 1031092

Shinya, Yokomizo

Search repository
Mayumi, Nishimura

× Mayumi, Nishimura

WEKO 1031093

Mayumi, Nishimura

Search repository
Takamitsu, Morioka

× Takamitsu, Morioka

WEKO 1031094

Takamitsu, Morioka

Search repository
Utako, Enzaka

× Utako, Enzaka

WEKO 1031095

Utako, Enzaka

Search repository
Chizuru, Tsuruoka

× Chizuru, Tsuruoka

WEKO 1031096

Chizuru, Tsuruoka

Search repository
Yi, Shang

× Yi, Shang

WEKO 1031097

Yi, Shang

Search repository
Yukiko, Nishimura

× Yukiko, Nishimura

WEKO 1031098

Yukiko, Nishimura

Search repository
Inoue, Kazumasa

× Inoue, Kazumasa

WEKO 1031099

Inoue, Kazumasa

Search repository
Fukushi, Masahiro

× Fukushi, Masahiro

WEKO 1031100

Fukushi, Masahiro

Search repository
Tatsuhiko, Imaoka

× Tatsuhiko, Imaoka

WEKO 1031101

Tatsuhiko, Imaoka

Search repository
Shizuko, Kakinuma

× Shizuko, Kakinuma

WEKO 1031102

Shizuko, Kakinuma

Search repository
Yoshiya, Shimada

× Yoshiya, Shimada

WEKO 1031103

Yoshiya, Shimada

Search repository
Shinya, Yokomizo

× Shinya, Yokomizo

WEKO 1031104

en Shinya, Yokomizo

Search repository
Mayumi, Nishimura

× Mayumi, Nishimura

WEKO 1031105

en Mayumi, Nishimura

Search repository
Takamitsu, Morioka

× Takamitsu, Morioka

WEKO 1031106

en Takamitsu, Morioka

Search repository
Utako, Enzaka

× Utako, Enzaka

WEKO 1031107

en Utako, Enzaka

Search repository
Chizuru, Tsuruoka

× Chizuru, Tsuruoka

WEKO 1031108

en Chizuru, Tsuruoka

Search repository
Yi, Shang

× Yi, Shang

WEKO 1031109

en Yi, Shang

Search repository
Yukiko, Nishimura

× Yukiko, Nishimura

WEKO 1031110

en Yukiko, Nishimura

Search repository
Tatsuhiko, Imaoka

× Tatsuhiko, Imaoka

WEKO 1031111

en Tatsuhiko, Imaoka

Search repository
Shizuko, Kakinuma

× Shizuko, Kakinuma

WEKO 1031112

en Shizuko, Kakinuma

Search repository
Yoshiya, Shimada

× Yoshiya, Shimada

WEKO 1031113

en Yoshiya, Shimada

Search repository
抄録
内容記述タイプ Abstract
内容記述 Abstract. Background: An enriched environment (EE) as an animal housing condition modifies apoptotic cell death and promotes cell proliferation in the central nervous system (CNS). However, few studies have examined the effects of an EE on apoptosis in non-CNS organs. Here we evaluated the effects of an EE on spontaneous and radiation-induced apoptosis of intestinal crypt cells. Materials and Methods: Juvenile (3 weeks after birth) and adult (11 weeks) male B6C3F1 mice were housed in a standard environment or EE for 8 weeks and then whole-body irradiated with 2 Gy X-rays. Apoptosis in the small intestine and colon was analyzed histologically by immunohistochemically using anti-cleaved caspase 3 antibody. Results: The EE used in this study significantly reduced body weight, adipose tissue weight, and serum levels of total-cholesterol, triglyceride, leptin, and insulin. Notably, although EE did not change the spontaneous apoptotic index without irradiation, it significantly increased the index after irradiation in the colonic crypt. Apoptosis therein was enhanced in the region where putative stem/progenitor cells are located. The apoptotic index in the small intestinal crypt showed similar patterns. Conclusion: EE enhances susceptibility to radiation-induced apoptosis of stem/progenitor cells in both small intestine and colon without affecting spontaneous apoptosis.
書誌情報 In Vivo

巻 36, 号 2, p. 618-627, 発行日 2022-03
出版者
出版者 International Institute of Anticancer Research
ISSN
収録物識別子タイプ ISSN
収録物識別子 0258-851X
DOI
識別子タイプ DOI
関連識別子 10.21873/invivo.12745
関連サイト
識別子タイプ URI
関連識別子 https://iv.iiarjournals.org/content/36/2/618
戻る
0
views
See details
Views

Versions

Ver.1 2023-05-15 16:59:10.680306
Show All versions

Share

Mendeley Twitter Facebook Print Addthis

Cite as

エクスポート

OAI-PMH
  • OAI-PMH JPCOAR 2.0
  • OAI-PMH JPCOAR 1.0
  • OAI-PMH DublinCore
  • OAI-PMH DDI
Other Formats
  • JSON
  • BIBTEX

Confirm


Powered by WEKO3


Powered by WEKO3