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Environmental Enrichment Increases Radiation-induced Apoptosis Not Spontaneous Apoptosis in Mouse Intestinal Crypt Cells
https://repo.qst.go.jp/records/85654
https://repo.qst.go.jp/records/856548550dc8c-0732-4149-b61e-ab21b68086b3
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2021-10-11 | |||||
| タイトル | ||||||
| タイトル | Environmental Enrichment Increases Radiation-induced Apoptosis Not Spontaneous Apoptosis in Mouse Intestinal Crypt Cells | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Shinya, Yokomizo
× Shinya, Yokomizo× Mayumi, Nishimura× Takamitsu, Morioka× Utako, Enzaka× Chizuru, Tsuruoka× Yi, Shang× Yukiko, Nishimura× Inoue, Kazumasa× Fukushi, Masahiro× Tatsuhiko, Imaoka× Shizuko, Kakinuma× Yoshiya, Shimada× Shinya, Yokomizo× Mayumi, Nishimura× Takamitsu, Morioka× Utako, Enzaka× Chizuru, Tsuruoka× Yi, Shang× Yukiko, Nishimura× Tatsuhiko, Imaoka× Shizuko, Kakinuma× Yoshiya, Shimada |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Abstract. Background: An enriched environment (EE) as an animal housing condition modifies apoptotic cell death and promotes cell proliferation in the central nervous system (CNS). However, few studies have examined the effects of an EE on apoptosis in non-CNS organs. Here we evaluated the effects of an EE on spontaneous and radiation-induced apoptosis of intestinal crypt cells. Materials and Methods: Juvenile (3 weeks after birth) and adult (11 weeks) male B6C3F1 mice were housed in a standard environment or EE for 8 weeks and then whole-body irradiated with 2 Gy X-rays. Apoptosis in the small intestine and colon was analyzed histologically by immunohistochemically using anti-cleaved caspase 3 antibody. Results: The EE used in this study significantly reduced body weight, adipose tissue weight, and serum levels of total-cholesterol, triglyceride, leptin, and insulin. Notably, although EE did not change the spontaneous apoptotic index without irradiation, it significantly increased the index after irradiation in the colonic crypt. Apoptosis therein was enhanced in the region where putative stem/progenitor cells are located. The apoptotic index in the small intestinal crypt showed similar patterns. Conclusion: EE enhances susceptibility to radiation-induced apoptosis of stem/progenitor cells in both small intestine and colon without affecting spontaneous apoptosis. | |||||
| 書誌情報 |
In Vivo 巻 36, 号 2, p. 618-627, 発行日 2022-03 |
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| 出版者 | ||||||
| 出版者 | International Institute of Anticancer Research | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0258-851X | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.21873/invivo.12745 | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | https://iv.iiarjournals.org/content/36/2/618 | |||||
