@article{oai:repo.qst.go.jp:00085654,
 author = {Shinya, Yokomizo and Mayumi, Nishimura and Takamitsu, Morioka and Utako, Enzaka and Chizuru, Tsuruoka and Yi, Shang and Yukiko, Nishimura and Inoue, Kazumasa and Fukushi, Masahiro and Tatsuhiko, Imaoka and Shizuko, Kakinuma and Yoshiya, Shimada and Shinya, Yokomizo and Mayumi, Nishimura and Takamitsu, Morioka and Utako, Enzaka and Chizuru, Tsuruoka and Yi, Shang and Yukiko, Nishimura and Tatsuhiko, Imaoka and Shizuko, Kakinuma and Yoshiya, Shimada},
 issue = {2},
 journal = {In Vivo},
 month = {Mar},
 note = {Abstract. Background: An enriched environment (EE) as an animal housing condition modifies apoptotic cell death and promotes cell proliferation in the central nervous system (CNS). However, few studies have examined the effects of an EE on apoptosis in non-CNS organs. Here we evaluated the effects of an EE on spontaneous and radiation-induced apoptosis of intestinal crypt cells. Materials and Methods: Juvenile (3 weeks after birth) and adult (11 weeks) male B6C3F1 mice were housed in a standard environment or EE for 8 weeks and then whole-body irradiated with 2 Gy X-rays. Apoptosis in the small intestine and colon was analyzed histologically by immunohistochemically using anti-cleaved caspase 3 antibody. Results: The EE used in this study significantly reduced body weight, adipose tissue weight, and serum levels of total-cholesterol, triglyceride, leptin, and insulin. Notably, although EE did not change the spontaneous apoptotic index without irradiation, it significantly increased the index after irradiation in the colonic crypt. Apoptosis therein was enhanced in the region where putative stem/progenitor cells are located. The apoptotic index in the small intestinal crypt showed similar patterns. Conclusion: EE enhances susceptibility to radiation-induced apoptosis of stem/progenitor cells in both small intestine and colon without affecting spontaneous apoptosis.},
 pages = {618--627},
 title = {Environmental Enrichment Increases Radiation-induced Apoptosis Not Spontaneous Apoptosis in Mouse Intestinal Crypt Cells},
 volume = {36},
 year = {2022}
}