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Homeostatic regulation of lipid droplet content in mammalian oocytes and embryos
https://repo.qst.go.jp/records/85650
https://repo.qst.go.jp/records/85650670b6450-4fbb-455b-9b50-5011a5b2ed33
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2021-11-10 | |||||
| タイトル | ||||||
| タイトル | Homeostatic regulation of lipid droplet content in mammalian oocytes and embryos | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Ibayashi, Megumi
× Ibayashi, Megumi× Aizawa, Ryutaro× Mitsui, Junichiro× Tsukamoto, Satoshi× Megumi, Ibayashi× Ryutaro, Aizawa× Junichiro, Mitsui× Satoshi, Tsukamoto |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Lipid droplets (LDs) consist of a core of neutral lipids such as triacylglycerols and cholesteryl esters covered by a phospholipid monolayer. Recent studies have shown that LDs not only store neutral lipids but are also associated with various physiological functions. LDs are found in most eukaryotic cells and vary in size and quantity. It has long been known that mammalian oocytes contain LDs. Porcine and bovine oocytes contain substantial amounts of LDs, which cause their cytoplasm to darken, whereas mouse and human oocytes are translucent due to their low LD content. A sufficient amount of LDs in mammalian oocytes has been thought to be associated with oocyte maturation and early embryonic development, but the necessity of LDs has been questioned because embryonic development proceeds normally even when LDs are removed. However, recent studies have revealed that LDs play a crucial role during implantation and that maintaining an appropriate amount of LDs is important for early embryonic development, even in mammalian species with low amounts of LDs in their oocytes. This suggests that a fine-tuned balance of LD content is essential for successful mammalian embryonic development. In this review, we discuss the physiological importance of LDs in mammalian oocytes and preimplantation embryos based on recent findings on LD biology. | |||||
| 書誌情報 |
Reproduction 巻 162, 号 6, p. R99-R109, 発行日 2021-10 |
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| 出版者 | ||||||
| 出版者 | Society for Reproduction and Fertility | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 1470-1626 | |||||
| PubMed番号 | ||||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 34715675 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1530/REP-21-0238 | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | https://rep.bioscientifica.com/view/journals/rep/162/6/REP-21-0238.xml | |||||
