@article{oai:repo.qst.go.jp:00085650,
 author = {Ibayashi, Megumi and Aizawa, Ryutaro and Mitsui, Junichiro and Tsukamoto, Satoshi and Megumi, Ibayashi and Ryutaro, Aizawa and Junichiro, Mitsui and Satoshi, Tsukamoto},
 issue = {6},
 journal = {Reproduction},
 month = {Oct},
 note = {Lipid droplets (LDs) consist of a core of neutral lipids such as triacylglycerols and cholesteryl esters covered by a phospholipid monolayer. Recent studies have shown that LDs not only store neutral lipids but are also associated with various physiological functions. LDs are found in most eukaryotic cells and vary in size and quantity. It has long been known that mammalian oocytes contain LDs. Porcine and bovine oocytes contain substantial amounts of LDs, which cause their cytoplasm to darken, whereas mouse and human oocytes are translucent due to their low LD content. A sufficient amount of LDs in mammalian oocytes has been thought to be associated with oocyte maturation and early embryonic development, but the necessity of LDs has been questioned because embryonic development proceeds normally even when LDs are removed. However, recent studies have revealed that LDs play a crucial role during implantation and that maintaining an appropriate amount of LDs is important for early embryonic development, even in mammalian species with low amounts of LDs in their oocytes. This suggests that a fine-tuned balance of LD content is essential for successful mammalian embryonic development. In this review, we discuss the physiological importance of LDs in mammalian oocytes and preimplantation embryos based on recent findings on LD biology.},
 pages = {R99--R109},
 title = {Homeostatic regulation of lipid droplet content in mammalian oocytes and embryos},
 volume = {162},
 year = {2021}
}